e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Optimization of 4-(N-cycloamino) phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site

XF Wang, F Guan, E Ohkoshi, W Guo…

Index: Dalence-Guzman, Maria F.; Berglund, Magnus; Skogvall, Staffan; Sterner, Olov Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2499 - 2512

Full Text: HTML

Citation Number: 8

Abstract

... of Medicinal Chemistry. ... Pharmacy Department, Urumqi General Hospital, Lanzhou Military Region, Urumqi 830000, China. # Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan. J. Med. Chem. ...

tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate Structure

tert-butyl 6-me...

~99%

1,2,3,4-Tetrahydroisoquinolin-6-ol hydrobrimide Structure

1,2,3,4-Tetrahy...

N-Methyl-3,4-dimethoxybenzylamine Structure

N-Methyl-3,4-di...

~99%

4-[(Methylamino)Methyl]pyrocatechol Hydrobromide Structure

4-[(Methylamino...

2-(3-methoxyphenyl)-N-methyleneethanamine Structure

2-(3-methoxyphe...

~%

6-Methoxy-1,2,3,4-tetrahydroisochinolin Structure

6-Methoxy-1,2,3...

8-Methoxy-1,2,3,4-tetrahydroisoquinoline Structure

8-Methoxy-1,2,3...

2-(3-methoxyphenyl)-N-methyleneethanamine Structure

2-(3-methoxyphe...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate Structure

tert-butyl 6-me...

tert-butyl 8-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate Structure

tert-butyl 8-me...

Salsolidine hydrochloride Structure

Salsolidine hyd...

~99%

6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-methyl-, hydrobromide (1:1) Structure

6,7-Isoquinolin...

6,7-Dimethoxy-2-tetralone Structure

6,7-Dimethoxy-2...

~63%

7,8-Dimethoxy-1,3,4,5-tetrahydrobenzo[d]azepin-2-one Structure

7,8-Dimethoxy-1...

7-Methoxy-3,4-dihydronaphthalen-2(1H)-one Structure

7-Methoxy-3,4-d...

~%

8-methoxy-1,2,4,5-tetrahydro-3H-2-benzazepin-3-one Structure

8-methoxy-1,2,4...

8-Methoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one Structure

8-Methoxy-4,5-d...

tert-butyl 7-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate Structure

tert-butyl 7-me...

~99%

1,2,3,4-tetrahydroisoquinolin-7-ol,hydrobromide Structure

1,2,3,4-tetrahy...

1,2-bis(bromomethyl)-4,5-dimethoxybenzene Structure

1,2-bis(bromome...

4-Toluenesulfonamide Structure

4-Toluenesulfonamide

~73%

5,6-dimethoxy-2-(4-methylphenyl)sulfonyl-1,3-dihydroisoindole Structure

5,6-dimethoxy-2...

7,8-Dimethoxy-1,3,4,5-tetrahydrobenzo[d]azepin-2-one Structure

7,8-Dimethoxy-1...

~44%

7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepine,hydrochloride Structure

7,8-dimethoxy-2...

Inhibition of phenylethanolamine N-methyltransferase (PNMT) ...

[Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2208 - 2216]

Inhibition of phenylethanolamine N-methyltransferase (PNMT) ...

[Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2208 - 2216]

Inhibition of phenylethanolamine N-methyltransferase (PNMT) ...

[Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2208 - 2216]

SAR based design of nicotinamides as a novel class of androg...

[Journal of Medicinal Chemistry, , vol. 56, # 8 p. 3414 - 3418]

SAR based design of nicotinamides as a novel class of androg...

[Journal of Medicinal Chemistry, , vol. 56, # 8 p. 3414 - 3418]