Journal of medicinal chemistry

Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1, 2, 3, 4-tetrahydroisoquinolines. Further studies on the hydrophilic …

DJ Sall, GL Grunewald

Index: Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2208 - 2216

Full Text: HTML

Citation Number: 39

Abstract

... The chemical shifts and multiplicity of the aryl hy- drogens in 16.HBr were consistent with those published for the corresponding hydrochloride salt.37 The 5-hydroxy- and 5-methoxy-1,2,3,4- tetrahydroiso- quinolines (14 and 18 ... Journal of Medicinal Chemistry, 1987, Vol. ...

 Related Synthetic Route
3-Methoxy-2-phenylethylamine Structure

2039-67-0

3-Methoxy-2-phe...

~%

1,2,3,4-Tetrahydroisoquinolin-6-ol hydrobrimide Structure

59839-23-5

1,2,3,4-Tetrahy...

6-Methoxy-3,4-dihydro-1(2H)-isoquinolinone Structure

22246-12-4

6-Methoxy-3,4-d...

~%

1,2,3,4-Tetrahydroisoquinolin-6-ol hydrobrimide Structure

59839-23-5

1,2,3,4-Tetrahy...

N-(methoxycarbonyl)-2-(3'-methoxyphenyl)ethylamine Structure

110192-21-7

N-(methoxycarbo...

~%

1,2,3,4-Tetrahydroisoquinolin-6-ol hydrobrimide Structure

59839-23-5

1,2,3,4-Tetrahy...

methyl N-[2-(4-methoxyphenyl)ethyl]carbamate Structure

91247-71-1

methyl N-[2-(4-...

~29%

7-Methoxy-3,4-dihydro-1(2H)-isoquinolinone Structure

22246-04-4

7-Methoxy-3,4-d...

4-Methoxyphenylethylamine Structure

55-81-2

4-Methoxyphenyl...

8-Methoxy-1,2,3,4-tetrahydroisoquinoline Structure

34146-68-4

8-Methoxy-1,2,3...

~83%

1,2,3,4-tetrahydroisoquinolin-8-ol,hydrobromide Structure

110192-20-6

1,2,3,4-tetrahy...

3,4-dihydro-8-Methoxyisoquinolin-1(2H)-one Structure

74904-29-3

3,4-dihydro-8-M...

~%

1,2,3,4-tetrahydroisoquinolin-8-ol,hydrobromide Structure

110192-20-6

1,2,3,4-tetrahy...

N-(methoxycarbonyl)-2-(3'-methoxyphenyl)ethylamine Structure

110192-21-7

N-(methoxycarbo...

~%

1,2,3,4-tetrahydroisoquinolin-8-ol,hydrobromide Structure

110192-20-6

1,2,3,4-tetrahy...

3-Methoxy-2-phenylethylamine Structure

2039-67-0

3-Methoxy-2-phe...

~%

1,2,3,4-tetrahydroisoquinolin-8-ol,hydrobromide Structure

110192-20-6

1,2,3,4-tetrahy...

N-(methoxycarbonyl)-5-methoxy-1,2,3,4-tetrahydroisoquinoline Structure

110192-24-0

N-(methoxycarbo...

~94%

Isoquinoline, 1,2,3,4-tetrahydro-5-methoxy-, hydrochloride (1:1) Structure

103030-69-9

Isoquinoline, 1...

5-Hydroxyisoquinoline Structure

2439-04-5

5-Hydroxyisoqui...

~%

Isoquinoline, 1,2,3,4-tetrahydro-5-methoxy-, hydrochloride (1:1) Structure

103030-69-9

Isoquinoline, 1...

Methyl 5-hydroxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate Structure

110192-23-9

Methyl 5-hydrox...

~%

Isoquinoline, 1,2,3,4-tetrahydro-5-methoxy-, hydrochloride (1:1) Structure

103030-69-9

Isoquinoline, 1...

N,O-bis(methoxycarbonyl)-5-hydroxy-1,2,3,4-tetrahydroisoquinoline Structure

110192-22-8

N,O-bis(methoxy...

~%

Isoquinoline, 1,2,3,4-tetrahydro-5-methoxy-, hydrochloride (1:1) Structure

103030-69-9

Isoquinoline, 1...

1,2,3,4-Tetrahydroisoquinolin-5-Ol Hydrochloride Structure

102879-34-5

1,2,3,4-Tetrahy...

~%

Isoquinoline, 1,2,3,4-tetrahydro-5-methoxy-, hydrochloride (1:1) Structure

103030-69-9

Isoquinoline, 1...


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