New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides

…, RA Ronfeld, PD McMaster, EW Byrnes

Index: Tenthorey; Block; Ronfeld; McMaster; Byrnes Journal of Medicinal Chemistry, 1981 , vol. 24, # 7 p. 798 - 806

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Citation Number: 29

Abstract

The synthesis and pharmacological evaluation of primary and tertiary aminoxylidides with the amino group in the 2-7 position of the acyl chain are described. 2, 6-Xylidine was acylated with haloacyl halides and converted to the target compounds by direct amination or by the Gabriel procedure. Alternatively, 2, 6-xylidine was coupled with keto acids, and the ketoxylidides were converted to the amines by reductive amination. The target compounds ...