Tocainide structure
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Common Name | Tocainide | ||
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CAS Number | 41708-72-9 | Molecular Weight | 192.25800 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C11H16N2O | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of TocainideTocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2]. |
Name | tocainide |
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Synonym | More Synonyms |
Description | Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2]. |
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Related Catalog | |
Target |
IC50: sodium channel[1] |
In Vivo | Tocainide (100 mg/kg) effectively suppresses ventricular ectopic activity in unanesthetized dogs with coronary occlusion. Termination of tocainide infusion in both digitalis toxicity and coronary occlusion models results in prompt return of ventricular ectopic activity[1]. |
References |
Molecular Formula | C11H16N2O |
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Molecular Weight | 192.25800 |
Exact Mass | 192.12600 |
PSA | 55.12000 |
LogP | 2.36240 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Hazard Codes | Xn: Harmful; |
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Risk Phrases | R22 |
HS Code | 2924299090 |
~% Tocainide CAS#:41708-72-9 |
Literature: Astra Pharmaceutical Products, Inc. Patent: US4218477 A1, 1980 ; US 4218477 A |
~% Tocainide CAS#:41708-72-9 |
Literature: Astra Pharmaceutical Products, Inc. Patent: US4218477 A1, 1980 ; US 4218477 A |
~% Tocainide CAS#:41708-72-9 |
Literature: Tenthorey; Block; Ronfeld; McMaster; Byrnes Journal of Medicinal Chemistry, 1981 , vol. 24, # 7 p. 798 - 806 |
HS Code | 2924299090 |
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Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
R/S-Tocainide |
2-amino-2',6'-propionoxylidide |
MFCD00072010 |
EINECS 255-505-0 |
TOCAINIDE |
6'-propionoxylidide,2-amino-2 |
alanyl-2,6-xylidide |