CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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TX1404500
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CHEMICAL NAME :
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Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, monohydrochloride
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CAS REGISTRY NUMBER :
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35891-93-1
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LAST UPDATED :
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199706
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DATA ITEMS CITED :
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4
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MOLECULAR FORMULA :
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C11-H16-N2-O.Cl-H
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MOLECULAR WEIGHT :
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228.75
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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48 mg/kg/2D-I
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TOXIC EFFECTS :
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Behavioral - hallucinations, distorted perceptions
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REFERENCE :
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PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 61,79,1985
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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257 mg/kg/15D-I
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Taste) - change in function Behavioral - tremor Skin and Appendages - dermatitis, other (after systemic exposure)
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REFERENCE :
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DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 22,142,1988
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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360 mg/kg/6W-I
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TOXIC EFFECTS :
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Blood - normocytic anemia Blood - agranulocytosis
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REFERENCE :
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AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 147,598,1987
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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529 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 15,192,1973
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