The synthesis and pharmacological evaluation of primary and tertiary aminoxylidides with the amino group in the 2-7 position of the acyl chain are described. 2, 6-Xylidine was acylated with haloacyl halides and converted to the target compounds by direct amination or by the Gabriel procedure. Alternatively, 2, 6-xylidine was coupled with keto acids, and the ketoxylidides were converted to the amines by reductive amination. The target compounds ...
