2,6-xylidine

Modify Date: 2024-01-02 10:51:24

2,6-xylidine Structure
2,6-xylidine structure
 Common Name 2,6-xylidine
CAS Number 87-62-7 Molecular Weight 121.180
Density 1.0±0.1 g/cm3 Boiling Point 217.9±0.0 °C at 760 mmHg
Molecular Formula C8H11N Melting Point 10-12 °C(lit.)
MSDS Chinese USA Flash Point 91.1±0.0 °C
Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09		 Signal Word Warning

 Names

Name 2,6-dimethylaniline
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 217.9±0.0 °C at 760 mmHg
Melting Point 10-12 °C(lit.)
Molecular Formula C8H11N
Molecular Weight 121.180
Flash Point 91.1±0.0 °C
Exact Mass 121.089149
PSA 26.02000
LogP 1.86
Vapour Pressure 0.1±0.4 mmHg at 25°C
Index of Refraction 1.559
Water Solubility 7.5 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZE9275000
CHEMICAL NAME :
2,6-Xylidine
CAS REGISTRY NUMBER :
87-62-7
BEILSTEIN REFERENCE NO. :
0636332
LAST UPDATED :
199710
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C8-H11-N
MOLECULAR WEIGHT :
121.20
WISWESSER LINE NOTATION :
ZR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
840 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis Blood - changes in spleen
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
707 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3150 mg/kg/20D-C
TOXIC EFFECTS :
Blood - changes in spleen
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6200 mg/kg/2W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
13300 mg/kg/4W-I
TOXIC EFFECTS :
Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20150 mg/kg/13W-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight Liver - changes in liver weight Blood - changes in other cell count (unspecified)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
107 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Endocrine - tumors

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
301 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7951 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)

 Safety Information

Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09
Signal Word Warning
Hazard Statements H302 + H312 + H332-H315-H335-H351-H411
Precautionary Statements P261-P273-P280
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases R20/21/22;R37/38;R40;R51/53
Safety Phrases S23-S25-S36/37-S61
RIDADR UN 1711 6.1/PG 2
WGK Germany 2
RTECS ZE9275000
Packaging Group II
Hazard Class 6.1
HS Code 29214910

 Synthetic Route

 Customs

HS Code 2921430090
Summary HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles30

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 Synonyms

o-Xylidine
2-Amino-1,3-xylene
2,6-dimethyl-aniline
Benzene, 2-amino-1,3-dimethyl-
1-amino-2,6-dimethybenzene
Benzenamine,2,6-dimethyl
2,6-xylidine
2,6-dimethylphenylamine
2,6-dimethylbenzeneamine
aniline, 2,6-dimethyl-
MFCD00007747
2-amino-1,3-dimethylbenzene
Benzenamine, 2,6-dimethyl-
2,6-Dimethylbenzenamine
2,6-Dimethylaniline
2-Amino-m-xylene
2,5-DIMETHOXYTOLUENE
1-amino-2,6-dimethylbenzene
2,6-methylaniline
EINECS 201-758-7
2,6-dimethyl aniline
Bupivacaine Impurity 8
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