BippyPhos: A single ligand with unprecedented scope in the Buchwald–Hartwig amination of (hetero) aryl chlorides

…, CB Lavery, M Stradiotto

Index: Crawford, Sarah M.; Lavery, Christopher B.; Stradiotto, Mark Chemistry - A European Journal, 2013 , vol. 19, # 49 p. 16760 - 16771

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Citation Number: 35

Abstract

Abstract Over the past two decades, considerable attention has been given to the development of new ligands for the palladium-catalyzed arylation of amines and related NH- containing substrates (ie, Buchwald–Hartwig amination). The generation of structurally diverse ligands, by research groups in both academia and industry, has facilitated the accommodation of sterically and electronically divergent substrates including ammonia, ...

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Chlorobenzene Structure

108-90-7

Chlorobenzene

2,4-Pentandione Structure

123-54-6

2,4-Pentandione

~93%

3,5-DIMETHYL-1-PHENYLPYRAZOLE Structure

1131-16-4

3,5-DIMETHYL-1-...

Dihexylamine Structure

143-16-8

Dihexylamine

Chlorobenzene Structure

108-90-7

Chlorobenzene

~64%

N,N-Dihexylaniline Structure

4430-09-5

N,N-Dihexylaniline

Benzamide Structure

55-21-0

Benzamide

4-Chlorobenzotrifluoride Structure

98-56-6

4-Chlorobenzotr...

~74%

N-[4-(Trifluoromethyl)phenyl]benzamide Structure

350-98-1

N-[4-(Trifluoro...

Indole Structure

120-72-9

Indole

1-Chloro-4-methoxybenzene Structure

623-12-1

1-Chloro-4-meth...

~71%

1-(4-methoxyphenyl)indole Structure

93597-01-4

1-(4-methoxyphe...

Methanesulfonamide Structure

3144-09-0

Methanesulfonamide

Chlorobenzene Structure

108-90-7

Chlorobenzene

~88%

Mesylaniline Structure

1197-22-4

Mesylaniline

4-Toluenesulfonamide Structure

70-55-3

4-Toluenesulfonamide

Chlorobenzene Structure

108-90-7

Chlorobenzene

~93%

P-TOLUENESULFONANILIDE Structure

68-34-8

P-TOLUENESULFON...

Acetamide Structure

60-35-5

Acetamide

Chlorobenzene Structure

108-90-7

Chlorobenzene

~81%

Acetanilide Structure

103-84-4

Acetanilide

2-Chloropyridine Structure

109-09-1

2-Chloropyridine

Acetamide Structure

60-35-5

Acetamide

~70%

N-(2-Pyridinyl)acetamide Structure

5231-96-9

N-(2-Pyridinyl)...

Indole Structure

120-72-9

Indole

Benzenesulfonic acid,4-methyl-, phenyl ester Structure

640-60-8

Benzenesulfonic...

~84%

phenylindole Structure

16096-33-6

phenylindole

(Z)-Methanimidic acid Structure

77287-34-4

(Z)-Methanimidi...

4-Chlorobenzotrifluoride Structure

98-56-6

4-Chlorobenzotr...

~96%

Formamide,N-[4-(trifluoromethyl)phenyl]- Structure

74702-40-2

Formamide,N-[4-...

2-Phenylindole Structure

948-65-2

2-Phenylindole

1-Chloro-4-methoxybenzene Structure

623-12-1

1-Chloro-4-meth...

~91%

1-(4-methoxyphenyl)-2-phenylindole Structure

52351-44-7

1-(4-methoxyphe...

1-Chloro-4-methoxybenzene Structure

623-12-1

1-Chloro-4-meth...

1-Phenyl-2-(2-chlorophenyl)ethyne Structure

10271-57-5

1-Phenyl-2-(2-c...

~72%

1-(4-methoxyphenyl)-2-phenylindole Structure

52351-44-7

1-(4-methoxyphe...

Pyrrole Structure

109-97-7

Pyrrole

Chlorobenzene Structure

108-90-7

Chlorobenzene

~92%

1-Phenylpyrrole Structure

635-90-5

1-Phenylpyrrole

Acetamide Structure

60-35-5

Acetamide

4-Chloro-2-methylquinoline Structure

4295-06-1

4-Chloro-2-meth...

~90%

N-(2-Methyl-4-quinolyl)acetamide Structure

52101-48-1

N-(2-Methyl-4-q...

2-Chloropyridine Structure

109-09-1

2-Chloropyridine

4-Toluenesulfonamide Structure

70-55-3

4-Toluenesulfonamide

~42%

4-methyl-N-pyridin-2-yl-benzenesulfonamide Structure

52776-76-8

4-methyl-N-pyri...

2-Chlorotoluene Structure

95-49-8

2-Chlorotoluene

Benzamide Structure

55-21-0

Benzamide

~97%

Benzamide,N-(2-methylphenyl)- Structure

584-70-3

Benzamide,N-(2-...

1-Chloro-4-methoxybenzene Structure

623-12-1

1-Chloro-4-meth...

Benzamide Structure

55-21-0

Benzamide

~98%

Benzamide,N-(4-methoxyphenyl)- Structure

7472-54-0

Benzamide,N-(4-...

Nicotinamide Structure

98-92-0

Nicotinamide

Chlorobenzene Structure

108-90-7

Chlorobenzene

~81%

N-Phenylnicotinamide Structure

1752-96-1

N-Phenylnicotinamide

3-Chloropyridine Structure

626-60-8

3-Chloropyridine

Benzamide Structure

55-21-0

Benzamide

~92%

N-pyridin-3-ylbenzamide Structure

5221-40-9

N-pyridin-3-ylb...


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