Butylmalonic acid
Butylmalonic acid structure
|
Common Name | Butylmalonic acid | ||
|---|---|---|---|---|
| CAS Number | 534-59-8 | Molecular Weight | 160.16800 | |
| Density | 1.197 g/cm3 | Boiling Point | 333.1ºC at 760 mmHg | |
| Molecular Formula | C7H12O4 | Melting Point | 105-107 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 169.4ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Phosphate-induced efflux of adenine nucleotides from rat-heart mitochondria: evaluation of the roles of the phosphate/hydroxyl exchanger and the dicarboxylate carrier.
Biochim. Biophys. Acta 893(3) , 470-9, (1987) Upon the addition of inorganic phosphate, isolated rat-heart mitochondria released endogenous adenine nucleotides. To elucidate the mechanism of this phosphate-induced efflux, we evaluated the relative roles of three inner mitochondrial membrane carriers: the... |
|
|
Inhibition by potential metabolic inhibitors of in vitro adipose tissue lipogenesis.
Comp. Biochem. Physiol.,. B. 81(3) , 667-70, (1985) To study the pathway of lactate utilization as a carbon source for fatty acid synthesis, the effect of (-)-hydroxycitrate, agaric acid, sodium oxamate, 2-n-butyl malonate and alpha-cyano-4-hydroxycinnamate on the rate of in vitro conversion of lactate, acetat... |
|
|
Ethylmalonic acid impairs brain mitochondrial succinate and malate transport.
Mol. Genet. Metab. 105(1) , 84-90, (2012) Tissue accumulation and high urinary excretion of ethylmalonic acid (EMA) occur in ethylmalonic encephalopathy (EE) and short chain acyl-CoA dehydrogenase deficiency (SCADD). Although these autosomal recessive disorders are clinically characterized by neurolo... |
|
|
The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic beta cells.
Diabetologia 54(1) , 135-45, (2011) We have previously described a strong correlation between pyruvate cycling and insulin secretion. We have also demonstrated a particularly important role for a pyruvate-isocitrate cycling pathway involving the mitochondrial citrate/isocitrate carrier (CIC) an... |
|
|
Total synthesis of (+/-)-actinophyllic acid.
J. Am. Chem. Soc. 130(24) , 7568-9, (2008) The first total synthesis of (+/-)-actinophyllic acid (1) is reported. Key steps of this synthesis include an intramolecular oxidative coupling of ketone and malonic ester enolates and an aza-Cope-Mannich rearrangement that assembled the core structure of the... |
|
|
Regulation of uncoupling protein activity in phosphorylating potato tuber mitochondria.
FEBS Lett. 579(20) , 4437-42, (2005) In isolated potato tuber mitochondria, palmitic acid (PA) can induce a H+ leak inhibited by GTP in the phosphorylating (state 3) respiration but not in the resting (state 4) respiration. The PA-induced H+ leak is constant when state 3 respiration is decreased... |
|
|
Isolation and reconstitution of the n-butylmalonate-sensitive dicarboxylate transporter from rat liver mitochondria.
J. Biol. Chem. 260(18) , 10293-8, (1985) The mitochondrial dicarboxylate carrier has been substantially purified from rat liver mitoplasts by extraction with Triton X-114 in the presence of cardiolipin followed by chromatography on hydroxylapatite. Upon incorporation of the hydroxylapatite eluate in... |
|
|
Calcium transport in bovine sperm mitochondria: effect of substrates and phosphate.
Biochim. Biophys. Acta 1026(1) , 57-63, (1990) Calcium uptake into filipin-treated bovine spermatozoa is completely inhibited by the uncoupler CCCP or by ruthenium red. Both Pi and mitochondrial substrates are required to obtain the maximal rate of calcium uptake into the sperm mitochondria. Bicarbonate a... |
|
|
Reducing-equivalent transfer to the mitochondria during gluconeogenesis and ureogenesis in hepatocytes from rats of different thyroid status.
Biochim. Biophys. Acta 1137(1) , 34-8, (1992) Isolated hepatocytes from hypothyroid, euthyroid and hyperthyroid rats have been employed to investigate the relative importance of reducing-equivalent shuttles for the transfer of hydrogen between cytoplasm and mitochondria during simultaneous ureogenesis an... |
|
|
The effects of some mitochondrial translocase inhibitors on the activity of rat liver transhydrogenase.
Biochem. Pharmacol. 31(22) , 3645-9, (1982) Non-energy dependent transhydrogenase activity in submitochondrial particles is stimulated at pH 8 by some inhibitors of mitochondrial carboxylate translocases. On solubilising the enzyme or assaying it at pH 6 these inhibitors have little effect. Km values r... |