M-6-G TRIFLUOROACETATE-HYDRATE
M-6-G TRIFLUOROACETATE-HYDRATE structure
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Common Name | M-6-G TRIFLUOROACETATE-HYDRATE | ||
|---|---|---|---|---|
| CAS Number | 20290-10-2 | Molecular Weight | 461.46200 | |
| Density | 1.64g/cm3 | Boiling Point | 731.6ºC at 760mmHg | |
| Molecular Formula | C23H27NO9 | Melting Point | 237-240°C (dec.) | |
| MSDS | Chinese USA | Flash Point | 396.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Morphine glucuronidation increases its analgesic effect in guinea pigs.
Life Sci. 109(2) , 104-10, (2014) Morphine is extensively metabolized to neurotoxic morphine-3-glucuronide (M3G) and opioid agonist morphine-6-glucuronide (M6G). Due to these different roles, interindividual variability and co-administration of drugs that interfere with metabolism may affect ... |
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[Rapid opiate detoxification under anesthesia (RODA)].
Rev. Med. Liege. 68(5-6) , 298-302, (2013) Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure the plasma concentrations of heroin metabolites and meth... |
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[Blood-brain barrier transport of opioid analgesics].
Yakugaku Zasshi 131(10) , 1445-51, (2011) Opioid analgesics exhibit cationic properties under physiological conditions, and the mechanism underlying permeation of the blood-brain barrier thus cannot be fully explained by simple diffusion alone. Various types of transporters that exhibit substrate spe... |
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Investigation of morphine and morphine glucuronide levels and cytochrome P450 isoenzyme 2D6 genotype in codeine-related deaths
Forensic Sci. Int. 220(1-3) , 6-11, (2012) Compared to morphine and morphine-6-glucuronide (M6G), codeine and its other major metabolites codeine-6-glucuronide and norcodeine have weak affinity to opioid μ-receptors. Analgesic effects of codeine are thus largely dependent on metabolic conversion to mo... |
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Effect of 12-oxochenodeoxycholate on the pharmacokinetics and pharmacodynamics of morphine 6-glucuronide in Wistar rats.
J. Pharm. Pharmacol. 65(4) , 561-6, (2013) The semi-synthetic bile salt, 12-oxochenodeoxycholate (OCDC also known as 12-monoketocholate), has been shown to enhance drug permeation across biological membranes with low cytotoxicity. Its effect on the analgesic potency and brain concentration of morphine... |
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Determination of opiates in whole blood and vitreous humor: a study of the matrix effect and an experimental design to optimize conditions for the enzymatic hydrolysis of glucuronides.
J. Anal. Toxicol. 36(3) , 162-70, (2012) Undoubtedly, whole blood and vitreous humor have been biological samples of great importance in forensic toxicology. The determination of opiates and their metabolites has been essential for better interpretation of toxicological findings. This report describ... |
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Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies.
J. Pharmacol. Exp. Ther. 349(1) , 126-37, (2014) Morphine 3-β-D-glucuronide (M3G) and morphine 6-β-D-glucuronide (M6G) are the major metabolites of morphine in humans. More recently, morphine-3-β-d-glucoside (M-3-glucoside) was identified in the urine of patients treated with morphine. Kinetic and inhibitio... |
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Cardiorespiratory, gastrointestinal, and analgesic effects of morphine sulfate in conscious healthy horses.
Am. J. Vet. Res. 73(6) , 799-808, (2012) To compare the cardiorespiratory, gastrointestinal, analgesic, and behavioral effects between IV and IM administration of morphine in conscious horses with no signs of pain.6 healthy adult horses.Horses received saline (0.9% NaCl) solution (IM or IV) or morph... |
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Contribution of morphine and morphine-6-glucuronide to respiratory depression in a child.
Anaesth. Intensive Care 40(5) , 867-70, (2012) A morphine plasma concentration/respiratory rate relationship has been described for both adults and children although that of its metabolite, morphine-6-glucuronide, remains uncertain. We describe this relationship in a child with end-stage renal failure who... |
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Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain.
Eur. J. Clin. Pharmacol. 68(8) , 1147-56, (2012) Our aim was to compare pharmacological aspects of two switching strategies from morphine/oxycodone to methadone; the stop and go (SAG) strategy in which methadone is started directly after the initial opioid has been stopped, and the 3-days switch (3DS), in w... |