Phenelzine (sulfate)
Phenelzine (sulfate) structure
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Common Name | Phenelzine (sulfate) | ||
|---|---|---|---|---|
| CAS Number | 156-51-4 | Molecular Weight | 234.27300 | |
| Density | N/A | Boiling Point | 497.4ºC at 760 mmHg | |
| Molecular Formula | C8H14N2O4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 254.6ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs.
Biol. Psychiatry 34(6) , 1467-81, (2009) Previous work has shown that repeated desipramine treatment causes downregulation of the norepinephrine transporter (NET) and persistent antidepressant-like effects on behavior, ie effects observed 2 days after discontinuation of drug treatment when acute eff... |
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Monoamine oxidase inhibitors revisited: what you should know.
J. Clin. Psychiatry 74(2) , 189-91, (2013)
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Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors.
J. Biomol. Screen. 17(7) , 957-65, (2012) The active metabolite of the chemotherapeutic irinotecan, SN-38, is detoxified through glucuronidation and then excreted into the gastrointestinal tract. Intestinal bacteria convert the glucuronidated metabolite back to the toxic SN-38 using β-glucuronidase (... |
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The antidepressant phenelzine enhances memory in the double Y-maze and increases GABA levels in the hippocampus and frontal cortex of rats
Pharmacol. Biochem. Behav. 102(1) , 109-17, (2012) Subchronic treatment with a non-competitive glutamate NMDA-receptor antagonist (e.g., MK-801, phencyclidine) or social isolation (SI) from weaning (age 21days) to adulthood (age 56days) produces deficits similar to some positive and negative symptoms of schiz... |
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Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments.
Brain Res. 1211 , 37-43, (2008) Antidepressant treatments have been proposed to produce their therapeutic effects, in part, through increasing neurotrophin levels in the brain. The current experiments investigated the effects of acute and chronic treatment with different pharmacologic and s... |
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Phenelzine mitochondrial functional preservation and neuroprotection after traumatic brain injury related to scavenging of the lipid peroxidation-derived aldehyde 4-hydroxy-2-nonenal.
J. Cereb. Blood Flow Metab. 33(4) , 593-9, (2013) Phenelzine (PZ) is a scavenger of the lipid peroxidation (LP)-derived reactive aldehyde 4-hydroxynonenal (4-HNE) due to its hydrazine functional group, which can covalently react with 4-HNE. In this study, we first examined the ability of PZ to prevent the re... |
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Differential effects of imipramine and phenelzine on corticosteroid receptor gene expression in mouse brain: potential relevance to antidepressant response.
Brain Res. 1238 , 93-107, (2008) Although glucocorticoid feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis is frequently impaired in depression, atypical depression may exhibit increased feedback sensitivity. Because monoamine oxidase inhibitors (MAOI) are often more effe... |
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Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raphé tryptophan hydroxylase gene expression.
Brain Res. 1288 , 69-78, (2009) Brainstem monoaminergic nuclei express glucocorticoid receptors (GR), and glucocorticoids have been shown to inhibit expression of enzymes involved in monoamine synthesis. Monoamine deficits have been implicated in depression pathology. However, it is unknown... |
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Phenelzine (monoamine oxidase inhibitor) increases production of nitric oxide and proinflammatory cytokines via the NF-κB pathway in lipopolysaccharide-activated microglia cells.
Neurochem. Res. 37(10) , 2117-24, (2012) Phenelzine is a potent monoamine oxidase inhibitor that is used in patients with depression. It is also well known that nitric oxide (NO) synthase inhibitors show preclinical antidepressant-like properties, which suggests that NO is involved in the pathogenes... |
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Potential antidepressant activity of Areca catechu nut via elevation of serotonin and noradrenaline in the hippocampus of rats.
Phytother Res. 27(1) , 39-45, (2013) The current study was aimed at investigating the potential antidepressant activity of Areca catechu nut ethanol extract and its various fractions using behavioral (acute and sub-chronic forced swim tests) and biochemical (monoamines and their metabolite level... |