Icaritin
Icaritin structure
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Common Name | Icaritin | ||
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| CAS Number | 118525-40-9 | Molecular Weight | 368.380 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 582.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H20O6 | Melting Point | 239ºC | |
| MSDS | Chinese USA | Flash Point | 206.7±23.6 °C | |
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Icaritin ameliorates carbon tetrachloride-induced acute liver injury mainly because of the antioxidative function through estrogen-like effects.
In Vitro Cell. Dev. Biol. Anim. 50(10) , 899-908, (2014) To investigate the effects of icaritin, an active ingredient extracted from Epimedium Sagittatum (Sieb. et Zucc.), on CCl4-induced liver injury and its possible mechanisms. Hepatocytes isolated from Sprague-Dawley male rats were treated with 3 mmol/L CCl4 for... |
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Icaritin induces lytic cytotoxicity in extranodal NK/T-cell lymphoma.
J. Exp. Clin. Cancer Res 34 , 17, (2015) Extranodal NK/T-cell lymphoma (ENKL) is an aggressive hematological malignancy associated with Epstein-Barr virus (EBV) infection. It is often resistant to conventional chemotherapy and has a poor prognosis. Icaritin, a compound derived from Chinese herbal me... |
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Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis--an in vitro efficacy study.
PLoS ONE 7 , e41264, (2012) We found that Icaritin, an intestinal metabolite of Epimedium-derived flavonoids (EF) enhanced osteoblastic differentiation of mesenchymal stem cells (MSCs) only under osteogenic induction conditions. We also demonstrated its effect on inhibition of adipogeni... |
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Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings.
PLoS ONE 6 , e23720, (2011) To explore the effects of Icaritin on chronic myeloid leukemia (CML) cells and underlying mechanisms.CML cells were incubated with various concentration of Icaritin for 48 hours, the cell proliferation was analyzed by MTT and the apoptosis was assessed with A... |
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Icaritin causes sustained ERK1/2 activation and induces apoptosis in human endometrial cancer cells.
PLoS ONE 6 , e16781, (2011) Icaritin, a compound from Epimedium Genus, has selective estrogen receptor (ER) modulating activities, and possess anti-tumor activity. Here, we examined icaritin effect on cell growth of human endometrial cancer Hec1A cells and found that icaritin potently i... |
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Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy.
Oncol. Rep. 35 , 334-42, (2015) Bladder cancer is one of the most commonly diagnosed urological malignancies. Acquired resistance to chemotherapy is a great barrier for achieving successful treatment of bladder cancer. In the present study, we investigated the effect and mechanisms of icari... |