680C91
680C91 structure
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Common Name | 680C91 | ||
|---|---|---|---|---|
| CAS Number | 163239-22-3 | Molecular Weight | 238.26000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H11FN2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS05 |
Signal Word | Danger | |
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A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer.
Cancer Res. 75 , 4651-64, (2015) The ability of a cancer cell to develop resistance to anoikis, a programmed cell death process triggered by substratum detachment, is a critical step in the metastatic cascade. Triple-negative breast cancers (TNBC) exhibit higher rates of metastasis after dia... |
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L-kynurenine/aryl hydrocarbon receptor pathway mediates brain damage after experimental stroke.
Circulation 130(23) , 2040-51, (2014) Aryl hydrocarbon receptor (AhR) is a transcription factor that belongs to the basic helix-loop-helix PAS (Per-Arnt-Sim homology domain) family known to mediate the toxic and carcinogenic effects of xenobiotics. Interestingly, AhR is widely expressed in the ce... |
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Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites.
.PubMed ID Metabolites of the kynurenine pathway (KP) of tryptophan (TRP) degradation have been closely linked to the pathogenesis of several neurodegenerative disorders. Recent work has highlighted the therapeutic potential of inhibiting two critical regulatory enzymes... |
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Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma.
J. Transl. Med. 10 , 247, (2013) Multiple myeloma (MM) is a plasma cell malignancy with a multifaceted immune dysfunction. Indoleamine 2,3-dioxygenase 1 (IDO1) degrades tryptophan into kynurenine (KYN), which inhibits effector T cells and promote regulatory T-cell (Treg) differentiation. It ... |