DL-AP5
DL-AP5 structure
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Common Name | DL-AP5 | ||
|---|---|---|---|---|
| CAS Number | 76326-31-3 | Molecular Weight | 197.13 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 482.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C5H12NO5P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 245.4±31.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Appetitive cue-evoked ERK signaling in the nucleus accumbens requires NMDA and D1 dopamine receptor activation and regulates CREB phosphorylation.
Learn. Mem. 21(11) , 606-15, (2014) Conditioned stimuli (CS) can modulate reward-seeking behavior. This modulatory effect can be maladaptive and has been implicated in excessive reward seeking and relapse to drug addiction. We previously demonstrated that exposure to an appetitive CS causes an ... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Anatomical and electrophysiological changes in striatal TH interneurons after loss of the nigrostriatal dopaminergic pathway.
Brain Struct. Funct. 220(1) , 331-49, (2015) Using transgenic mice that express enhanced green fluorescent protein (EGFP) under the control of the tyrosine hydroxylase (TH) promoter, we have previously shown that there are approximately 3,000 striatal EGFP-TH interneurons per hemisphere in mice. Here, w... |
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Cholinergic control of gamma power in the midbrain spatial attention network.
J. Neurosci. 35(2) , 761-75, (2015) The modulation of gamma power (25-90 Hz) is associated with attention and has been observed across species and brain areas. However, mechanisms that control these modulations are poorly understood. The midbrain spatial attention network in birds generates hig... |
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Dopamine D1 and D5 receptors modulate spike timing-dependent plasticity at medial perforant path to dentate granule cell synapses.
J. Neurosci. 34(48) , 15888-97, (2014) Although evidence suggests that DA modulates hippocampal function, the mechanisms underlying that dopaminergic modulation are largely unknown. Using perforated-patch electrophysiological techniques to maintain the intracellular milieu, we investigated how the... |
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Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
J. Neurosci. 35(14) , 5680-92, (2015) Cholinergic [acetylcholine (ACh)] axons from the basal forebrain innervate olfactory bulb glomeruli, the initial site of synaptic integration in the olfactory system. Both nicotinic acetylcholine receptors (nAChRs) and muscarinic acetylcholine receptors (mACh... |
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Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
J. Neurosci. 35(14) , 5664-79, (2015) The Ca(2+) channelopathies caused by mutations of the CACNA1A gene that encodes the pore-forming subunit of the human Cav2.1 (P/Q-type) voltage-gated Ca(2+) channel include episodic ataxia type 2 (EA2). Although, in EA2 the emphasis has been on cerebellar dys... |
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Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
Mol. Brain 8 , 35, (2015) Voltage-sensitive dye (VSD) imaging and intrinsic optical signals (IOS) are widely used methods for monitoring spatiotemporal neural activity in extensive networks. In spite of that, identification of their major cellular and molecular components has not been... |
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A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model.
Mol. Pharmacol. 88 , 460-8, (2015) In the spinal cord and periphery, adenosine inhibits neuronal activity through activation of the adenosine A1 receptor (A1R), resulting in antinociception and highlighting the potential of therapeutically targeting the receptor in the treatment of neuropathic... |
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Toll-like receptor 4 enhancement of non-NMDA synaptic currents increases dentate excitability after brain injury.
Neurobiol. Dis. 74 , 240-53, (2015) Concussive brain injury results in neuronal degeneration, microglial activation and enhanced excitability in the hippocampal dentate gyrus, increasing the risk for epilepsy and memory dysfunction. Endogenous molecules released during injury can activate innat... |