PX-12
PX-12 structure
|
Common Name | PX-12 | ||
|---|---|---|---|---|
| CAS Number | 141400-58-0 | Molecular Weight | 188.314 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 330.0±25.0 °C at 760 mmHg | |
| Molecular Formula | C7H12N2S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 153.4±23.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
The overexpression and nuclear translocation of Trx-1 during hypoxia confers on HepG2 cells resistance to DDP, and GL-V9 reverses the resistance by suppressing the Trx-1/Ref-1 axis.
Free Radic. Biol. Med. 82 , 29-41, (2015) Microenvironmental hypoxia gives many tumor cells the capacity for drug resistance. Thioredoxin family members play critical roles in the regulation of cellular redox homeostasis in a stressed environment. In this study, we established a hypoxia-drug resistan... |
|
|
Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma.
Oncotarget 6 , 15410-24, (2015) Multiple myeloma (MM) is a hematological malignancy characterized by the aberrant accumulation of clonal plasma cells in the bone marrow. Despite recent advancement in anti-myeloma treatment, MM remains an incurable disease. This study showed higher intrinsic... |
|
|
Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA.
PLoS ONE 8 , e77277, (2013) To investigate the role of thioredoxin (TRX), a novel regulator of extracellular transglutaminase 2 (TG2), in celiac patients IgA (CD IgA) mediated TG2 enzymatic activation.TG2 enzymatic activity was evaluated in endothelial cells (HUVECs) under different exp... |
|
|
Identification and expression of Fasciola gigantica thioredoxin.
Parasitol. Res. 113(6) , 2335-43, (2014) In the present study, a cDNA encoding Trx from F. gigantica (FgTrx) was cloned by polymerase chain reaction (PCR). The sequence of FgTrx, analyzed by BLAST, SignalP, and ClustralW programs, showed 315 bp of an open reading frame (ORF), 12 bp 5'UTR, 78 bp 3'UT... |