BCTC
BCTC structure
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Common Name | BCTC | ||
|---|---|---|---|---|
| CAS Number | 393514-24-4 | Molecular Weight | 372.892 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 561.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H25ClN4O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 293.4±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Polysulfide evokes acute pain through the activation of nociceptive TRPA1 in mouse sensory neurons.
Mol. Pain 11 , 24, (2015) Hydrogen sulfide (H2S) is oxidized to polysulfide. Recent reports show that this sulfur compound modulates various biological functions. We have reported that H2S is involved in inflammatory pain in mice. On the other hand, little is known about the functiona... |
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Agonist-dependent modulation of cell surface expression of the cold receptor TRPM8.
J. Neurosci. 35(2) , 571-82, (2015) The spatial and temporal distribution of receptors constitutes an important mechanism for controlling the magnitude of cellular responses. Several members of the transient receptor potential (TRP) ion channel family can regulate their function by modulating t... |
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Temperature oscillations drive cycles in the activity of MMP-2,9 secreted by a human trabecular meshwork cell line.
Invest. Ophthalmol. Vis. Sci. 56(2) , 1396-405, (2015) Aqueous humor inflow falls 50% during sleeping hours without proportional fall in IOP, partly reflecting reduced outflow facility. The mechanisms underlying outflow facility cycling are unknown. One outflow facility regulator is matrix metalloproteinase (MMP)... |
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Direct evidence for functional TRPV1/TRPA1 heteromers.
Pflugers Arch. 466(12) , 2229-41, (2014) Transient receptor potential cation channel, subfamily V, member 1 (TRPV1) plays a key role in sensing environmental hazards and in enhanced pain sensation following inflammation. A considerable proportion of TRPV1-expressing cells also express transient rece... |
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Cigarette smoke has sensory effects through nicotinic and TRPA1 but not TRPV1 receptors on the isolated mouse trachea and larynx.
Am. J. Physiol. Lung Cell. Mol. Physiol. 309 , L812-20, (2015) Cigarette smoke (CS) exposes chemosensory nerves in the airways to a multitude of chemicals, some acting through the irritant receptors TRPV1 and TRPA1 but potentially also through nicotinic acetylcholine receptors (nAChR). Our aim was to characterize the dif... |
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TRPM8 Channel Activation Induced by Monoterpenoid Rotundifolone Underlies Mesenteric Artery Relaxation.
PLoS ONE 10 , e0143171, (2015) In this study, our aims were to investigate transient receptor potential melastatin-8 channels (TRPM8) involvement in rotundifolone induced relaxation in the mesenteric artery and to increase the understanding of the role of these thermosensitive TRP channels... |
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Full-length transient receptor potential vanilloid 1 channels mediate calcium signals and possibly contribute to osmoreception in vasopressin neurones in the rat supraoptic nucleus.
Cell Calcium 57(1) , 25-37, (2015) Neurones in the supraoptic nucleus (SON) of the hypothalamus possess intrinsic osmosensing mechanisms, which are lost in transient receptor potential vanilloid 1 (Trpv1)-knock-out mice. The molecular nature of the osmosensory mechanism in SON neurones is beli... |
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Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis.
J. Clin. Invest. 124(9) , 3793-806, (2014) The intestinal epithelium has a high rate of turnover, and dysregulation of pathways that regulate regeneration can lead to tumor development; however, the negative regulators of oncogenic events in the intestinal epithelium are not fully understood. Here we ... |
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3-Iodothyronamine increases transient receptor potential melastatin channel 8 (TRPM8) activity in immortalized human corneal epithelial cells.
Cell. Signal. 28 , 136-47, (2016) 3-Iodothyronamine (3T1AM) is an endogenous thyroid hormone metabolite that interacts with the human trace amine-associated receptor 1 (hTAAR1), a G-protein-coupled receptor, to induce numerous physiological responses including dose-dependent body temperature ... |