Oligomycin
Oligomycin structure
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Common Name | Oligomycin | ||
|---|---|---|---|---|
| CAS Number | 1404-19-9 | Molecular Weight | 2371.171 | |
| Density | 1.14 g/cm3 | Boiling Point | 886.3ºC at 760 mmHg | |
| Molecular Formula | C135H220O33 | Melting Point | 84-100ºC | |
| MSDS | Chinese USA | Flash Point | 252ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Thermogenic activity of UCP1 in human white fat-derived beige adipocytes.
Mol. Endocrinol. 29(1) , 130-9, (2014) Heat-producing beige/brite (brown-in-white) adipocytes in white adipose tissue have the potential to suppress metabolic disease in mice and hold great promise for the treatment of obesity and type 2 diabetes in humans. Here, we demonstrate that human adipose-... |
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Mitochondrial function provides instructive signals for activation-induced B-cell fates.
Nat. Commun. 6 , 6750, (2015) During immune reactions, functionally distinct B-cell subsets are generated by stochastic processes, including class-switch recombination (CSR) and plasma cell differentiation (PCD). In this study, we show a strong association between individual B-cell fates ... |
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Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells.
Sci. Rep. 5 , 16895, (2015) Mechanical cues direct the lineage commitment of mesenchymal stem cells (MSCs). In this study, we identified the operative molecular mechanisms through which dynamic tensile loading (DL) regulates changes in chromatin organization and nuclear mechanics in MSC... |
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Up-regulation of avian uncoupling protein in cold-acclimated and hyperthyroid ducklings prevents reactive oxygen species production by skeletal muscle mitochondria.
BMC Physiol. 10 , 5, (2010) Although identified in several bird species, the biological role of the avian homolog of mammalian uncoupling proteins (avUCP) remains extensively debated. In the present study, the functional properties of isolated mitochondria were examined in physiological... |
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Identification of ataxia-associated mtDNA mutations (m.4052T>C and m.9035T>C) and evaluation of their pathogenicity in transmitochondrial cybrids.
Muscle Nerve 40 , 381-94, (2009) The potential pathogenicity of two homoplasmic mtDNA point mutations, 9035T>C and 4452T>C, found in a family afflicted with maternally transmitted cognitive developmental delay, learning disability, and progressive ataxia was evaluated using transmitochondria... |
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Alterations in bioenergetics due to changes in mitochondrial DNA copy number.
Methods , (2010) All mitochondrial DNA (mtDNA)-encoded genes are involved in mitochondrial electron transport and ATP production. Alterations of mtDNA due to dysfunctional mitochondrial DNA polymerase gamma (POLG) induce loss of mitochondrial oxidative phosphorylation (OXPHOS... |
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The lipophilic weak base (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4-piperidinopyridine (AU-1421) is a potent protonophore type cationic uncoupler of oxidative phosphorylation in mitochondria.
Biochim. Biophys. Acta 1141 , 231-237, (1993) The lipophilic weak base AU-1421 acts as a simple protonophoric uncoupler of oxidative phosphorylation in rat liver mitochondria judging from the following observations. In the absence of any carrier lipophilic anions or P(i), AU-1421 stimulated the rate of s... |
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Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model.
Innate Immunity 16 , 67-79, (2010) Lactoferrin is a non-heme iron-binding glycoprotein, produced by mucosal epithelial cells and granulocytes in most mammalian species. It is involved in regulation of immune responses, possesses anti-oxidant, anti-carcinogenic, anti-inflammatory properties, an... |
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PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease.
Hum. Mol. Genet. 25 , 792-806, (2016) Mitochondrial anomalies have been previously reported in patients' brain and peripheral tissue, suggesting their relevance in sporadic Alzheimer's disease (AD). The present work evaluates mitochondrial function and recycling in human fibroblasts and brain bio... |