Demoxepam
Demoxepam structure
|
Common Name | Demoxepam | ||
|---|---|---|---|---|
| CAS Number | 963-39-3 | Molecular Weight | 286.71300 | |
| Density | 1.37g/cm3 | Boiling Point | 447.4ºC at 760mmHg | |
| Molecular Formula | C15H11ClN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 224.4ºC | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
|
Liquid chromatography of demoxepam and phenothiazines using a post-column photochemical reactor and fluorescence detection.
J. Chromatogr. A. 217 , 463-71, (1981) Upon irradiation with short-wavelength UV light the tranquillizer demoxepam is converted into a highly fluorescent product. This reaction serves as a sensitive and selective means of detection of low levels of demoxepam in e.g., serum after separation by mean... |
|
|
The rapid hydrolysis of chlordiazepoxide to demoxepam may affect the outcome of chronic osmotic minipump studies.
Psychopharmacology 208(4) , 555-62, (2010) In chronic studies, the classical benzodiazepine chlordiazepoxide (CDP) is often the preferred drug because, unlike other benzodiazepines, it is soluble in water. However, rapid CDP hydrolysis in solution has been described. This would diminish plasma levels ... |
|
|
Methods for the determination of lorazepam and chlordiazepoxide and metabolites in brain tissue. A comparison with plasma concentrations in the rat.
J. Chromatogr. A. 277 , 201-8, (1983) Rapid and sensitive methods are described for determining lorazepam and for determining chlordiazepoxide and its metabolites in brain tissue of the rat. Lorazepam was determined by means of solvent extraction and electron-capture gas-liquid chromatography and... |
|
|
Assay of chlordiazepoxide and demoxepam in chlordiazepoxide formulations by difference spectrophotometry.
J. Pharm. Sci. 73(1) , 55-8, (1984) Rapid difference spectrophotometric methods for chlordiazepoxide and demoxepam in chlordiazepoxide formulations are described which overcome the nonspecificity of the official spectrophotometric assays. The procedures are based on the measurement of the diffe... |
|
|
Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat.
Brain Res. 290(1) , 183-6, (1984) Methods for determining Ro 15-1788 in brain tissue were developed using gas chromatography with nitrogen-phosphorus detection, and using reverse-phase high performance liquid chromatography. Application of the methods to pharmacokinetic studies in the rat fou... |
|
|
Use of direct-probe mass spectrometry as a toxicology confirmation method for demoxepam in urine following high-performance liquid chromatography.
J. Chromatogr. B, Biomed. Appl. 683(2) , 199-208, (1996) The identification of the metabolite demoxepam in human urine establishes that chlordiazepoxide, a common benzodiazepine, has been administered. Like N-oxide metabolites of other drugs, demoxepam cannot be detected by gas chromatography-mass spectrometry (GC-... |
|
|
Toxicity in a case of acute and massive overdose of chlordiazepoxide and its correlation to blood concentration.
J. Toxicol. Clin. Toxicol. 27(1-2) , 117-27, (1989) In previous studies no correlation between blood concentration and toxicity was found in acute chlordiazepoxide overdose. We describe a case of acute overdosage with 5.2 g chlordiazepoxide, in which toxicity correlated to blood concentration of the second met... |
|
|
Inhibitory effect of demoxepam on tryptophan binding to rat hepatic nuclei.
Biochem. Med. Metab. Biol. 47(3) , 270-3, (1992) Since some patients with eosinophilia-myalgia syndrome ingested tryptophan along with benzodiazepines, we investigated whether demoxepam, the N-desalkylated compound of chlordiazepoxide, would influence the binding of tryptophan to hepatic nuclei. L-Tryptopha... |
|
|
The use of bonded-phase extraction columns for rapid sample preparation of benzodiazepines and metabolites from serum for HPLC analysis.
J. Chromatogr. Sci. 19(11) , 562-6, (1981) A simple, rapid method for the determination of the benzodiazepines, diazepam and chlordiazepoxide, and their metabolites by high performance liquid chromatography (HPLC) has been developed. The procedure is applicable to the assay of other similar drugs in b... |
|
|
In vitro cytotoxicity study of oxaziridines generated after chlordiazepoxide, demoxepam, and desmethylchlordiazepoxide UV irradiation.
Drug Chem. Toxicol. 32(4) , 417-23, (2009) The cytotoxicity of oxaziridines photogenerated after irradiation of chlordiazepoxide (CDZ) and its metabolites was investigated in vitro by a MTT assay on P388 leukemia and B16 melanoma cell lines and compared with that of the anticancer drug, melphalan. For... |