diisopropyl fluorophosphate
diisopropyl fluorophosphate structure
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Common Name | diisopropyl fluorophosphate | ||
|---|---|---|---|---|
| CAS Number | 55-91-4 | Molecular Weight | 184.14600 | |
| Density | 1.06 g/mL at 25 °C(lit.) | Boiling Point | 62 °C9 mm Hg(lit.) | |
| Molecular Formula | C6H14FO3P | Melting Point | −82 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 64.5ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Structural insights into the broad substrate specificity of carboxypeptidase T from Thermoactinomyces vulgaris.
FEBS J. 282(7) , 1214-24, (2015) The crystal structures of carboxypeptidase T (CpT) complexes with phenylalanine and arginine substrate analogs - benzylsuccinic acid and (2-guanidinoethylmercapto)succinic acid - were determined by the molecular replacement method at resolutions of 1.57 Å and... |
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Characterization of Species Differences in Tissue Diltiazem Deacetylation Identifies Ces2a as a Rat-Specific Diltiazem Deacetylase.
Drug Metab. Dispos. 43 , 1218-25, (2015) Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previously reported that the area under the curve ratio of deacetyld... |
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Modulation of endothelial cell integrity and inflammatory activation by commercial lipid emulsions.
Lipids Health Dis. 14 , 9, (2015) Thrombosis and immune dysfunction are two important complications that result from the administration of parenteral nutrition. Endothelial cells within the vasculature are crucial components necessary for maintenance of normal coagulation and immune function.... |
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Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients.
PLoS ONE 10(2) , e0117775, (2015) Lysine-specific gingipain (Kgp) is a virulence factor secreted from Porphyromonas gingivalis (P. gingivalis), a major etiological bacterium of periodontal disease. Keratin intermediate filaments maintain the structural integrity of gingival epithelial cells, ... |
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[Safe use of biological therapies for the treatment of rheumatoid arthritis and spondyloarthritides].
Rev. Bras. Reumatol. 55 , 281-309, (2015) The treatment of autoimmune rheumatic diseases has gradually improved over the last half century, which has been expanded with the contribution of biological therapies or immunobiopharmaceuticals. However, we must be alert to the possibilities of undesirable ... |
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A dual component heme biosensor that integrates heme transport and synthesis in bacteria.
J. Microbiol. Methods 118 , 7-17, (2015) Bacterial pathogens acquire host iron to power cellular processes and replication. Heme, an iron-containing cofactor bound to hemoglobin, is scavenged by bacterial proteins to attain iron. Methods to measure intracellular heme are laborious, involve complex c... |
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Activation of TAK1 by Chemotactic and Growth Factors, and Its Impact on Human Neutrophil Signaling and Functional Responses.
J. Immunol. 195 , 5393-403, (2015) The MAP3 kinase, TAK1, is known to act upstream of IKK and MAPK cascades in several cell types, and is typically activated in response to cytokines (e.g., TNF, IL-1) and TLR ligands. In this article, we report that in human neutrophils, TAK1 can also be activ... |
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The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines.
J. Immunol. 195 , 2383-95, (2015) Myeloid leukocyte recruitment into the lung in response to environmental cues represents a key factor for the induction of lung damage. We report that Hck- and Fgr-deficient mice show a profound impairment in early recruitment of neutrophils and monocytes in ... |
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Chitosan-shelled oxygen-loaded nanodroplets abrogate hypoxia dysregulation of human keratinocyte gelatinases and inhibitors: New insights for chronic wound healing.
Toxicol. Appl. Pharmacol. 286 , 198-206, (2015) In chronic wounds, efficient epithelial tissue repair is hampered by hypoxia, and balances between the molecules involved in matrix turn-over such as matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are seriously impaired. ... |
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An in vitro and in vivo evaluation of the efficacy of recombinant human liver prolidase as a catalytic bioscavenger of chemical warfare nerve agents.
Drug Chem. Toxicol. 38(1) , 37-43, (2015) In this study, we determined the ability of recombinant human liver prolidase to hydrolyze nerve agents in vitro and its ability to afford protection in vivo in mice. Using adenovirus containing the human liver prolidase gene, the enzyme was over expressed by... |