Morantel tartrate
Morantel tartrate structure
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Common Name | Morantel tartrate | ||
|---|---|---|---|---|
| CAS Number | 26155-31-7 | Molecular Weight | 370.421 | |
| Density | N/A | Boiling Point | 334.6ºC at 760 mmHg | |
| Molecular Formula | C16H22N2O6S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 156.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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In vitro characterization of anthelmintic susceptibility of field isolates of the pig nodular worm Oesophagostomum spp., susceptible or resistant to various anthelmintics.
Int. J. Parasitol. 26(7) , 733-40, (1996) A larval development assay (LDA) and an egg hatch paralysis assay (EHPA) were used to measure the sensitivity to anthelmintics of eggs and larvae of nodular worms (Oesophagostomum spp.) in pigs. The tests were carried out using in vivo defined resistant and s... |
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Evaluation of broad-spectrum anthelmintic activity in a novel assay against Haemonchus contortus, Trichostrongylus colubriformis and T. sigmodontis in the gerbil Meriones unguiculatus.
J. Helminthol. 80(4) , 393-6, (2006) The gerbil Meriones unguiculatus, infected with three species of nematodes, each located in a separate part of the gastrointestinal tract, provided a reliable laboratory assay for the evaluation of broad-spectrum anthelmintic activity. Gerbils harbouring 6-da... |
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Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiation.
Mol. Pharmacol. 81 , 239-249, (2012) We are interested in the allosteric modulation of neuronal nicotinic acetylcholine receptors (nAChRs). We have postulated that the anthelmintic morantel (Mor) positively modulates (potentiates) rat α3β2 receptors through a site located at the β(+)/α(-) interf... |
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Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors.
Mol. Pharmacol. 74 , 466-475, (2008) We studied allosteric potentiation of rat alpha3beta2 neuronal nicotinic acetylcholine receptors (nAChRs) by the anthelmintic compound morantel. Macroscopic currents evoked by acetylcholine (ACh) from nAChRs expressed in Xenopus laevis oocytes increase up to ... |
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Efficacy of moxidectin and other anthelmintics against small strongyles in horses.
Aust. Vet. J. 76(5) , 332-4, (1998) To compare the efficacy of moxidectin to ivermectin, oxibendazole and morantel against some gastrointestinal nematodes in horses.Faecal egg count reduction after treatment.A farm was selected where the population of small strongyles in horses was known to be ... |
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The in vitro secretion of acetylcholinesterase by adult stages of Heligmosomoides polygyrus: the effects of broad-spectrum anthelmintics.
J. Vet. Med. B. Infect. Dis. Vet. Public Health 47(1) , 1-8, (2000) The secretion of acetylcholinesterase (AChE) by female and male Heligmosomoides polygyrus was studied in different in vitro culture media. AChE secretion was increased in the presence of fetal calf serum or bovine serum albumin (BSA). In the absence of crowdi... |
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Determination of N-methyl-1,3-propanediamine in bovine muscle by liquid chromatography with triple quadrupole and ion trap tandem mass spectrometry detection.
J. Chromatogr. A. 1235 , 103-14, (2012) Morantel, pyrantel and their drug-related metabolites in food of animal-origin are regulated as sum of residues which may be hydrolysed to N-methyl-1,3-propanediamine (NMPA). In this study, an isotope dilution liquid chromatography tandem mass spectrometry (L... |
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Anthelmintic actions on homomer-forming nicotinic acetylcholine receptor subunits: chicken alpha7 and ACR-16 from the nematode Caenorhabditis elegans.
Neuroscience 101(3) , 785-91, (2000) Two homomer-forming nicotinic acetylcholine receptor subunits with 47% identity in their amino acid sequences were employed to compare the actions of cholinergic anthelmintics and ivermectin on expressed vertebrate and nematode nicotinic receptors of known mo... |
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A survey of anthelmintic resistance by nematodes on three sheep and two goat farms in Hisar (India).
Vet. Res. Commun. 21(6) , 447-51, (1997)
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Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors.
J. Biol. Chem. 284(32) , 21478-87, (2009) Nicotinic receptors (AChRs) play key roles in synaptic transmission. We explored activation of neuronal alpha7 and mammalian muscle AChRs by morantel and oxantel. Our results revealed a novel action of morantel as a high efficacy and more potent agonist than ... |