Pimonidazole
Pimonidazole structure
|
Common Name | Pimonidazole | ||
|---|---|---|---|---|
| CAS Number | 70132-50-2 | Molecular Weight | 254.286 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 490.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C11H18N4O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 250.5±31.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Loss of the Notch effector RBPJ promotes tumorigenesis.
J. Exp. Med. 212(1) , 37-52, (2015) Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding t... |
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Right Ventricular Angiogenesis is an Early Adaptive Response to Chronic Hypoxia-Induced Pulmonary Hypertension.
Microcirculation 22 , 724-736, (2016) Myocardial angiogenesis is presumed to play a role in RV adaptation to PH, though definitive evidence and functional correlations are lacking. We aimed to use definitive methods to correlate RV angiogenesis, hypertrophy, and function in a murine PH model.Mice... |
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Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling.
Oncotarget 5(20) , 9664-77, (2014) Hypoxia is a common phenomenon occurring in the majority of human tumors and has been proved to play an important role in tumor progression. However, it remains unclear that whether the action of hypoxia on macrophages is a main driving force of hypoxia-media... |
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Preclinical and Clinical Evidence of Mycobacterium tuberculosis Persistence in the Hypoxic Niche of Bone Marrow Mesenchymal Stem Cells after Therapy.
Am. J. Pathol. 185 , 1924-34, (2015) Mycobacterium tuberculosis (MTB), the causative agent of pulmonary tuberculosis, is difficult to eliminate by antibiotic therapy. We recently identified CD271(+) bone marrow-mesenchymal stem cells (BM-MSCs) as a potential site of MTB persistence after therapy... |
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Renal oxygenation in acute renal ischemia-reperfusion injury.
Am. J. Physiol. Renal Physiol. 306(9) , F1026-38, (2014) Tissue hypoxia has been demonstrated, in both the renal cortex and medulla, during the acute phase of reperfusion after ischemia induced by occlusion of the aorta upstream from the kidney. However, there are also recent clinical observations indicating relati... |
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Nintedanib Is a Highly Effective Therapeutic for Neuroendocrine Carcinoma of the Pancreas (PNET) in the Rip1Tag2 Transgenic Mouse Model.
Clin. Cancer Res. 21 , 4856-67, (2015) Pancreatic neuroendocrine tumors (PNET) represent a rare but challenging heterogeneous group of cancers with an increasing incidence over the last number of decades. Herein, we report an in-depth evaluation of the new antiangiogenic small-molecule tyrosine ki... |
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Vessel maturation schedule determines vulnerability to neuronal injuries of prematurity.
J. Clin. Invest. 125(3) , 1319-28, (2015) Premature birth is a major risk factor for multiple brain pathologies, notably periventricular leukomalacia (PVL), which is distinguished by bilateral necrosis of neural tissue around the ventricles and a sequela of neurological disturbances. The 2 hallmarks ... |
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Vascular heterogeneity between native rat pancreatic islets is responsible for differences in survival and revascularisation post transplantation.
Diabetologia 58(1) , 132-9, (2014) Highly blood-perfused islets have been observed to be the most functional islets in the native pancreas. We hypothesised that differences in vascular support of islets in donor pancreases influence their susceptibility to cellular stress and capacity for vasc... |
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Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer.
Mol. Cancer Ther. 14 , 1504-16, (2015) Because dormant cancer cells in hypoxic and nutrient-deprived regions of solid tumors provide a major obstacle to treatment, compounds targeting those cells might have clinical benefits. Here, we describe a high-throughput drug screening approach, using gluco... |
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The timing of surgery after neoadjuvant radiotherapy influences tumor dissemination in a preclinical model.
Oncotarget 6 , 36825-37, (2015) Neoadjuvant radiotherapy (neoRT) used in cancer treatments aims at improving local tumor control and patient overall survival. The neoRT schedule and the timing of the surgical treatment (ST) are empirically based and influenced by the clinician's experience.... |