1,9-Dideoxyforskolin
1,9-Dideoxyforskolin structure
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Common Name | 1,9-Dideoxyforskolin | ||
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| CAS Number | 64657-18-7 | Molecular Weight | 378.50200 | |
| Density | 1.12 g/cm3 | Boiling Point | 455ºC at 760 mmHg | |
| Molecular Formula | C22H34O5 | Melting Point | 149-150ºC | |
| MSDS | Chinese USA | Flash Point | 146.9ºC | |
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Roles of calcium/calmodulin-dependent kinase II in long-term memory formation in crickets.
PLoS ONE 9(9) , e107442, (2014) Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a key molecule in many systems of learning and memory in vertebrates, but roles of CaMKII in invertebrates have not been characterized in detail. We have suggested that serial activation of NO/cG... |
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Inhibition of Akt reverses the acquired resistance to sorafenib by switching protective autophagy to autophagic cell death in hepatocellular carcinoma.
Mol. Cancer Ther. 13(6) , 1589-98, (2014) Sorafenib is the standard first-line systemic drug for advanced hepatocellular carcinoma (HCC), but the acquired resistance to sorafenib results in limited benefits. Activation of Akt is thought to be responsible for mediating the acquired resistance to soraf... |
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The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1.
Pflugers Arch. 442(1) , 49-56, (2001) The aim of the present study was to characterize depolarization-activated outward currents in insulin-secreting INS-1 cells and to investigate the role of K+ channels other than the KATP channels in the regulation of insulin release. Outward currents were inh... |
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Effect of protein kinase A-induced phosphorylation on the gating mechanism of the brain Na+ channel: model fitting to whole-cell current traces.
Biophys. J. 77(1) , 204-16, (1999) The activity of the voltage-gated Na+ channel is subjected to modulation through covalent modifications. It has been previously shown that brain Na+ currents are reduced following the activation of the protein kinase A (PKA) pathway, but the effect of the pho... |
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Synthetic transformation of ptychantin into forskolin and 1,9-dideoxyforskolin.
J. Org. Chem. 71(12) , 4619-24, (2006) Forskolin (1), a highly oxygenated labdane diterpenoid and an activator of adenylate cyclase, has been synthesized in 12 steps and 12% overall yield from ptychantin A (4), which has been isolated from liverwort Ptychanthus striatus in good yield. The 1alpha-h... |
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Volume sensitive efflux of taurine in HEK293 cells overexpressing phospholemman.
Biochim. Biophys. Acta 1496(2-3) , 252-60, (2000) The role of the phospholemman (PLM) on the efflux of taurine and chloride induced by swelling was studied in HEK293 cells overexpressing stable transfected PLM. PLM, a substrate for protein kinases C and A, is a protein that induces an anion current in Xenopu... |
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The adenylyl cyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38 MAPK and NF-kappaB in HaCaT keratinocytes.
Mol. Immunol. 46(10) , 1925-34, (2009) Patients with atopic dermatitis (AD) have significantly reduced plasma cAMP levels, and the cAMP level is correlated with the immunopathogenesis of AD. The production of thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (... |
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Differential actions of PKA and PKC in the regulation of glutamate release by group III mGluRs in the entorhinal cortex.
J. Neurophysiol. 85(2) , 571-9, (2001) In a previous study we showed that activation of a presynaptically located metabotropic glutamate receptor (mGluR) with pharmacological properties of mGluR4a causes a facilitation of glutamate release in layer V of the rat entorhinal cortex (EC) in vitro. In ... |
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Therapy for X-adrenoleukodystrophy: normalization of very long chain fatty acids and inhibition of induction of cytokines by cAMP.
J. Lipid Res. 39(5) , 1091-100, (1998) X-adrenoleukodystrophy (X-ALD) is an inherited fatty acid metabolic disorder with secondary manifestation of neuroinflammatory disease process. We report that compounds (forskolin, 8-bromo cAMP, and rolipram) that increase cAMP and activate protein kinase A (... |
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Adenylate cyclase and potassium channels are involved in forskolin- and 1,9-dideoxyforskolin-induced inhibition of pregnant rat uterus contractility.
Am. J. Obstet. Gynecol. 182(3) , 620-4, (2000) We sought to study the contribution of potassium channels in the effect of forskolin and 1,9-dideoxyforskolin on uterine contractility in the pregnant rat.Rings taken from the middle portions of uterine horns from rats at 16 days of gestation were positioned ... |