(3-Phenoxyphenyl)methanol
(3-Phenoxyphenyl)methanol structure
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Common Name | (3-Phenoxyphenyl)methanol | ||
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| CAS Number | 13826-35-2 | Molecular Weight | 200.233 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 377.8±0.0 °C at 760 mmHg | |
| Molecular Formula | C13H12O2 | Melting Point | 4-7°C | |
| MSDS | Chinese USA | Flash Point | 151.3±17.4 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Perturbation of rat heart plasma membrane fluidity due to metabolites of permethrin insecticide.
Cardiovasc. Toxicol. 11(3) , 226-34, (2011) Due to increased global use, acute and chronic exposures to pyrethroid insecticides in humans are of clinical concern. Pyrethroids have a primary mode of action that involves interference with the sodium and calcium channels in excitable cells, which may incl... |
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[Gas chromatographic determination of butyl alcohols in the atmospheric air].
Gig. Sanit. (2) , 68-9, (1990)
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The in vitro metabolism of a pyrethroid insecticide, permethrin, and its hydrolysis products in rats.
Toxicology 235(3) , 176-84, (2007) The in vitro metabolism of permethrin and its hydrolysis products in rats was investigated. Cis- and trans-permethrin were mainly hydrolyzed by liver microsomes, and also by small-intestinal microsomes of rats. trans-Permethrin was much more effectively hydro... |
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Evaluation of the stereoselective biotransformation of permethrin in human liver microsomes: Contributions of cytochrome P450 monooxygenases to the formation of estrogenic metabolites
Toxicol. Lett. 226(2) , 192-7, (2014) • Permethrin undergoes stereoselective oxidase and esterase metabolism in human liver microsomes. • Sequential metabolism from the esterase cleavage product PBOH to the oxidized product 3,4-PBOH is stereoselective for 1R-trans PM. • 1S-cis PM consistently has... |
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Identification and characterisation of Aedes aegypti aldehyde dehydrogenases involved in pyrethroid metabolism.
PLoS ONE 9(7) , e102746, (2014) Pyrethroid insecticides, especially permethrin and deltamethrin, have been used extensively worldwide for mosquito control. However, insecticide resistance can spread through a population very rapidly under strong selection pressure from insecticide use. The ... |
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Development of sensitive immunoassays for the detection of the glucuronide conjugate of 3-phenoxybenzyl alcohol, a putative human urinary biomarker for pyrethroid exposure.
J. Agric. Food Chem. 55(10) , 3750-7, (2007) Pyrethroids are widely used in agriculture as insecticides. This study describes a sensitive enzyme-linked immunosorbent assay for the detection of the glucuronide conjugate of 3-phenoxybenzyl alcohol, a putative pyrethroid metabolite that may be used as a bi... |
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[The hygienic standardization of 3-phenoxybenzyl alcohol in the atmospheric air of populated places].
Gig. Sanit. (6) , 6-8, (1995) The threshold level of 3-phenoxybenzyl alcohol (3-PBA) in ambient air was set up at 0.48 mg/m3. Inhalation of 3-PBA in concentrations of 4.86 and 0.518 mg/m3 caused changes in the central nervous system, metabolic processes, liver function, reduced the nonspe... |
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Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases.
Toxicol. Appl. Pharmacol. 221(1) , 1-12, (2007) Hydrolytic metabolism of pyrethroid insecticides in humans is one of the major catabolic pathways that clear these compounds from the body. Rodent models are often used to determine the disposition and clearance rates of these esterified compounds. In this st... |
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The pyrethroid metabolites 3-phenoxybenzoic acid and 3-phenoxybenzyl alcohol do not exhibit estrogenic activity in the MCF-7 human breast carcinoma cell line or Sprague-Dawley rats.
Toxicology 267(1-3) , 39-44, (2010) Synthetic pyrethroids are one of the most frequently and widely used class of insecticides, primarily because they have a higher insect to mammalian toxicity ratio than organochlorines or organophosphates. The basic structure of pyrethroids can be characteriz... |
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In vitro metabolism of trans-permethrin and its major metabolites, PBalc and PBacid, in humans.
J. Agric. Food Chem. 59(9) , 5001-5, (2011) To estimate the metabolic profile of trans-permethrin in humans, a comparison of the in vitro metabolism of trans-permethrin in humans and rats was conducted using hepatic microsomes, and cytochrome P450 and UDP-glucuronyltransferase isoforms, which catalyze ... |