Dibenzyl diisopropylphosphoramidoite
Dibenzyl diisopropylphosphoramidoite structure
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Common Name | Dibenzyl diisopropylphosphoramidoite | ||
|---|---|---|---|---|
| CAS Number | 108549-23-1 | Molecular Weight | 345.42 | |
| Density | 1.028 g/mL at 25 °C(lit.) | Boiling Point | 382.0±31.0 °C at 760 mmHg | |
| Molecular Formula | C20H28NO2P | Melting Point | N/A | |
| MSDS | USA | Flash Point | 184.8±24.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor.
Angew. Chem. Int. Ed. Engl. 53(1) , 199-204, (2014) We report the synthesis of a GDP analogue, SML-8-73-1, and a prodrug derivative, SML-10-70-1, which are selective, direct-acting covalent inhibitors of the K-Ras G12C mutant relative to wild-type Ras. Biochemical and biophysical measurements suggest that modi... |
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Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody.
Mol. Endocrinol. 14(1) , 52-65, (2000) Human progesterone receptor (PR) is phosphorylated on multiple serine residues (at least seven sites) in a manner that involves distinct groups of sites coordinately regulated by hormone and different kinases. Progress on defining a functional role for PR pho... |
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A new reaction for the direct conversion of 4-azido-4-deoxy-D-galactoside into a 4-deoxy-D-erythro-hexos-3-ulose.
Org. Lett. 6 , 1365-1368, (2004) [reaction: see text] A new one-step reaction has been developed for converting 4-azido-4-deoxy-d-galactoside into 4-deoxy-d-erythro-hexos-3-ulose by phosphoramidites and tetrazole. It is proposed that the new reaction proceeds via an intramolecular Staudinger... |
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Solid-phase synthesis of a range of O-phosphorylated peptides by post-assembly phosphitylation and oxidation.
Int. J. Pept. Protein Res. 38(5) , 469-75, (1991) A completely general method for the O-phosphorylation of peptides of any given composition using solid-phase methodology is described. Peptides were assembled using Fmoc amino acid active esters, with base used for Fmoc deprotection. Unprotected amino acid si... |
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Polyphosphates and pyrophosphates of hexopyranoses as allosteric effectors of human hemoglobin: synthesis, molecular recognition, and effect on oxygen release.
ChemMedChem 6(1) , 153-68, (2011) Polyphosphorylated and perphosphorylated hexopyranose monosaccharides and disaccharides were synthesized from parent or partially protected carbohydrates as potential allosteric effectors of hemoglobin. A study toward the construction of seven- and eight-memb... |
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Synthesis 9 , 1481-1485, (2004)
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