5-Iodotubercidin
5-Iodotubercidin structure
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Common Name | 5-Iodotubercidin | ||
|---|---|---|---|---|
| CAS Number | 24386-93-4 | Molecular Weight | 392.150 | |
| Density | 2.5±0.1 g/cm3 | Boiling Point | 701.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C11H13IN4O4 | Melting Point | 216-217ºC dec. | |
| MSDS | Chinese USA | Flash Point | 378.0±32.9 °C | |
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Chaperoning of the A1-adenosine receptor by endogenous adenosine - an extension of the retaliatory metabolite concept.
Mol. Pharmacol. 87(1) , 39-51, (2015) Cell-permeable orthosteric ligands can assist folding of G protein-coupled receptors in the endoplasmic reticulum (ER); this pharmacochaperoning translates into increased cell surface levels of receptors. Here we used a folding-defective mutant of human A1-ad... |
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Endothelial and Neuronal Nitric Oxide Activate Distinct Pathways on Sympathetic Neurotransmission in Rat Tail and Mesenteric Arteries.
PLoS ONE 10 , e0129224, (2015) Nitric oxide (NO) seems to contribute to vascular homeostasis regulating neurotransmission. This work aimed at assessing the influence of NO from different sources and respective intracellular pathways on sympathetic neurotransmission, in two vascular beds. E... |
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An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat.
Neuropharmacology 97 , 160-70, (2015) Adenosine kinase (AK) inhibitor is a potential candidate for controlling pain, but some AK inhibitors have problems of adverse effects such as motor impairment. ABT-702, a non-nucleoside AK inhibitor, shows analgesic effect in animal models of pain. Here, we ... |
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Inosine strongly enhances proliferation of human C32 melanoma cells through PLC-PKC-MEK1/2-ERK1/2 and PI3K pathways.
Basic Clin Pharmacol Toxicol. 116(1) , 25-36, (2014) Malignant melanoma is the most deadly type of skin cancer. The lack of effective pharmacological approaches for this tumour can be related to the incomplete understanding of the pathophysiological mechanisms involved in melanoma cell proliferation. Adenosine ... |
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The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
Cell Death Dis. 6 , e1629, (2015) The NLR pyrin domain containing 3 (NLRP3) inflammasome is a major component of the innate immune system, but its mechanism of activation by a wide range of molecules remains largely unknown. Widely used nano-sized inorganic metal oxides such as silica dioxide... |
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Adenosine Attenuates Human Coronary Artery Smooth Muscle Cell Proliferation by Inhibiting Multiple Signaling Pathways That Converge on Cyclin D.
Hypertension 66 , 1207-19, (2015) The goal of this study was to determine whether and how adenosine affects the proliferation of human coronary artery smooth muscle cells (HCASMCs). In HCASMCs, 2-chloroadenosine (stable adenosine analogue), but not N(6)-cyclopentyladenosine, CGS21680, or N(6)... |
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AICAR Enhances the Phagocytic Ability of Macrophages towards Apoptotic Cells through P38 Mitogen Activated Protein Kinase Activation Independent of AMP-Activated Protein Kinase.
PLoS ONE 10 , e0127885, (2015) Recent studies have suggested that 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) increases macrophage phagocytosis through adenosine monophosphate-activated protein kinase (AMPK). However, little information is available on the effects of AICAR ... |
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Identification of anti-proliferative kinase inhibitors as potential therapeutic agents to treat canine osteosarcoma.
Vet. J. 205 , 281-7, (2015) Osteosarcoma is the most common primary bone tumour in dogs but various forms of therapy have not significantly improved clinical outcomes. As dysregulation of kinase activity is often present in tumours, kinases represent attractive molecular targets for can... |
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Adenosine A1 receptor blockage mediates theophylline-associated seizures.
Epilepsia 51(3) , 483-7, (2010) Theophylline-associated seizures (TAS) often progress to prolonged or treatment-resistant convulsions. Theophylline is a nonselective adenosine receptor antagonist. Adenosine is an endogenous anticonvulsant that can terminate seizures. Fever and young age hav... |
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Physiological concentrations of divalent magnesium ion activate the serine/threonine specific protein kinase ERK2.
Biochemistry 42(10) , 2960-70, (2003) Extracellular regulated protein kinase 2 (ERK2) is a eukaryotic protein kinase whose activity is regulated by phorbol esters, serum, and growth factors, and displays enhanced activity in several human tumors. Despite its important biological function, its mec... |