Bromotrichloromethane
Bromotrichloromethane structure
|
Common Name | Bromotrichloromethane | ||
|---|---|---|---|---|
| CAS Number | 75-62-7 | Molecular Weight | 198.27400 | |
| Density | 2.012 g/mL at 25 °C(lit.) | Boiling Point | 105 °C(lit.) | |
| Molecular Formula | CBrCl3 | Melting Point | −6 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 104-105°C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Increased proteolysis after single-dose exposure with hepatotoxins in HepG2 cells.
Free Radic. Biol. Med. 33(2) , 283-91, (2002) Chronic ethanol consumption is associated with increased protein oxidation and decreased proteolysis in the liver. We tested the hypothesis that even single-dose treatment with ethanol or bromotrichloromethane causes increased protein oxidation and a distinct... |
|
|
Suicidal inactivation of haemoproteins by reductive metabolites of halomethanes: a structure-activity relationship study.
Toxicology 100(1-3) , 175-83, (1995) Human haemoglobin (Hb), methaemalbumin (MHA) or rat liver microsomal cytochrome P-450 (P-450) were incubated anaerobically at microM concentrations with 1 mM carbon tetrachloride (CCl4), trichlorobromomethane (CCl3Br), chloroform (CHCl3) or methylene chloride... |
|
|
Use of rat liver slices for the study of oxidative DNA damage in comparison with isolated rat liver nuclei and HepG2 human hepatoma cells.
Food Chem. Toxicol. 38(5) , 451-8, (2000) Tissue slices are a useful biological system for lipid peroxidation studies but their use for DNA damage studies is not well characterized. Hence, the present study investigates DNA damage in rat liver slices, in comparison with isolated rat liver nuclei and ... |
|
|
Metabolism-based transformation of myoglobin to an oxidase by BrCCl3 and molecular modeling of the oxidase form.
J. Biol. Chem. 268(4) , 2953-9, (1993) The stoichiometric reductive debromination of BrCCl3 to a trichloromethyl radical by myoglobin caused the prosthetic heme to become covalently cross-linked to the protein moiety and transformed myoglobin from an oxygen storage protein to an oxidase. This was ... |
|
|
The role of glutathione and protein thiols in CBrCl3-induced cytotoxicity in isolated rat hepatocytes.
Pharmacol. Toxicol. 75(1) , 7-16, (1994) The role of glutathione (GSH) and protein thiols in the pathobiochemical process of CBrCl3 cytotoxicity was investigated in isolated hepatocytes. Administration of 0.5, 1.0 and 1.5 mmol/l CBrCl3 affected cellular viability as assessed by trypan blue exclusion... |
|
|
Postexercise improvement in insulin-stimulated glucose uptake occurs concomitant with greater AS160 phosphorylation in muscle from normal and insulin-resistant rats.
Biofactors 24(1-4) , 89-96, (2005) Earlier research on rats with normal insulin sensitivity demonstrated that acute exercise increased insulin-stimulated glucose uptake (GU) concomitant with greater phosphorylation of Akt substrate of 160 kDa (pAS160). Because mechanisms for exercise effects o... |
|
|
Structure of the novel heme adduct formed during the reaction of human hemoglobin with BrCCl3 in red cell lysates.
J. Biol. Chem. 269(22) , 15481-7, (1994) It was previously shown that the reductive debromination of BrCCl3 to trichloromethyl radical by human hemoglobin leads to formation of dissociable altered heme products, two of which are identical to those formed from myoglobin and one which is novel. In thi... |
|
|
Trichlorobromomethane-induced changes of purine nucleotides in hepatocytes.
Biochem. Mol. Biol. Int. 31(3) , 405-12, (1993) The changes in nucleotide content during CBrCl3 treatment were investigated. In the first 5-10 minutes a significant ATP decrease was detected. The GTP loss leading to 57% of the initial level after 10 min surpasses the ATP loss which leads to 70% of the init... |
|
|
In vivo studies on halogen compound interactions. IV. Interaction among different halogen derivatives with and without synergistic action on liver toxicity.
Res. Commun. Chem. Pathol. Pharmacol. 76(3) , 355-66, (1992) The liver toxicity of several halogen compound mixtures have been tested. The compounds were selected on the basis of their metabolic pathways: carbon tetrachloride (CT) and trichlorobromomethane (TCBM) undergo a dehalogenation via P450-dependent enzyme syste... |
|
|
Heme oxygenase active-site residues identified by heme-protein cross-linking during reduction of CBrCl3.
Biochemistry 37(9) , 2889-96, (1998) The reduction of CBrCl3 by the heme-heme oxygenase complex forms dissociable and covalently bound heme products. No such products are formed with mesoheme in which the heme vinyl substituents are replaced by ethyl groups. The dissociable heme products are chr... |