4,5-Dimethylthiazole
4,5-Dimethylthiazole structure
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Common Name | 4,5-Dimethylthiazole | ||
|---|---|---|---|---|
| CAS Number | 3581-91-7 | Molecular Weight | 113.181 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 158.1±9.0 °C at 760 mmHg | |
| Molecular Formula | C5H7NS | Melting Point | 83-84ºC | |
| MSDS | Chinese USA | Flash Point | 51.1±0.0 °C | |
| Symbol |
GHS02, GHS05, GHS07 |
Signal Word | Danger | |
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Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation.
BMC Cancer 14 , 921, (2014) There is evidence that calcium (Ca(2+)) increases the proliferation of human advanced prostate cancer (PCa) cells but the ion channels involved are not fully understood. Here, we investigated the correlation between alpha(1D)-adrenergic receptor (alpha(1D)-AR... |
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Chemical Composition and Biological Activities of Allium roseum L. var. grandiflorum Briq. Essential Oil.
J. Oleo Sci. 64 , 869-79, (2015) Allium roseum L. (Alliaceae) endemic mediterranean specie was represented in the North Africa by 12 different taxa. In the present study, chemical composition, antiproliferative, antioxidant and antimicrobial activities of the essential oil extracted from A. ... |
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Effects of mesenchymal stem/stromal cells on cultures of corneal epithelial progenitor cells with ethanol injury.
Invest. Ophthalmol. Vis. Sci. 55(11) , 7628-35, (2014) Mesenchymal stem/stromal cells (MSCs) facilitate the regeneration of injured tissue. Our group has previously shown that human MSCs (hMSCs) or hMSC-derived factors suppress excessive inflammatory response in the cornea following chemical injury in vivo. We he... |
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Incorporation of eicosatrienoic acid exerts mild anti-inflammatory properties in murine RAW264.7 cells.
Inflammation 38(2) , 534-45, (2015) Eicosatrienoic acid (Δ11,14,17-20:3; ETrA) is a rare naturally occurring n-3 polyunsaturated fatty acid (PUFA). Using murine RAW264.7 cells, the objectives were to determine how ETrA modulated phospholipid fatty acid compositions and the production of pro-inf... |
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Targeted inhibition of galectin 1 by thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.
Int. J. Obes. 39 , 1349-58, (2015) Galectin 1 (GAL1), an animal lectin is well characterized in the context of cancer, tumor environment, but its physiological roles in obesity remain to be demonstrated. In this study, we investigated whether targeted inhibition of GAL1 prevents obesity based ... |
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Amphiphilic PEO-b-PBLG diblock and PBLG-b-PEO-b-PBLG triblock copolymer based nanoparticles: doxorubicin loading and in vitro evaluation.
Macromol. Biosci. 15(1) , 124-37, (2015) Huisgen's 1,3-dipolar cycloaddition ("Click Chemestry") has been used to prepare amphiphilic PEO-b-PBLG diblock and PBLG-b-PEO-b-PBLG triblock copolymers as potential carriers of anticancer drugs. Spherical and flower shaped micelles (D ≈ 100 nm) were obtaine... |
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Saturated Fatty Acid inhibits viral replication in chronic hepatitis B virus infection with nonalcoholic Fatty liver disease by toll-like receptor 4-mediated innate immune response.
Hepat. Mon. 15 , e27909, (2015) Chronic Hepatitis B (CHB) infection is common in patients with Non-Alcoholic Fatty Liver Disease (NAFLD). The replication level of Hepatitis B Virus (HBV) was inversely correlated with hepatic steatosis. Toll-Like Receptor (TLR) 4-mediated innate immunity pla... |
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Insulin Modulates In Vitro Secretion of Cytokines and Cytotoxins by Human Glial Cells.
Curr. Alzheimer Res. 12 , 684-93, (2015) Alzheimer's disease (AD) is the most common form of dementia worldwide. Type 2 diabetes (T2D) has been implicated as a risk factor for AD. Since T2D is a peripheral inflammatory condition, and AD brains exhibit exacerbated neuroinflammation, we hypothesized t... |
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Generation and Trapping of 4-Methylene-5-(bromomethylene)-4,5-dihydrothiazole with Dienophiles.
J. Org. Chem. 62(2) , 405-410, (1997) 4-(Bromomethyl)-5-(dibromomethyl)thiazole (1) was prepared in good yields by bromination of 4,5-dimethylthiazole with 3.3 equiv of NBS in the presence of AIBN. Treatment of 1 with sodium iodide led to a thiazole o-quinodimethane 2 which was trapped in situ wi... |
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Co-delivery of Sildenafil (Viagra(®)) and Crizotinib for synergistic and improved anti-tumoral therapy.
Pharm. Res. 31(9) , 2516-28, (2014) Cancer multi-drug resistance is a major issue associated with current anti-tumoral therapeutics. In this work, Crizotinib an anti-tumoral drug approved for the treatment of non-small lung cancer in humans, and Sildenafil (Viagra(®)), were loaded into micellar... |