Salmon Calcitonin Acetate
Salmon Calcitonin Acetate structure
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Common Name | Salmon Calcitonin Acetate | ||
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| CAS Number | 47931-85-1 | Molecular Weight | 3431.853 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C145H240N44O48S2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier.
Biomaterials 33(34) , 8881-92, (2012) The objective of the present study was to demonstrate the effect of polyanionic copolymer mPEG-grafted-alginic acid (mPEG-g-AA)-based polyion complex (PIC) micelles on enhancing the oral absorption of salmon calcitonin (sCT) in vivo and in vitro and identify ... |
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[Osteoporotic fractures: not only in females].
Rev. Med. Suisse 10(424) , 767-8, (2014)
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Decline in calcitonin receptor expression in osteocytes with age.
J. Endocrinol. 221(2) , 181-91, (2014) We have previously shown that co-administration of the transient osteoclast inhibitor, salmon calcitonin (sCT), blunts the anabolic effect of parathyroid hormone (PTH) in young rats and increases osteocytic expression of the bone formation inhibitor sclerosti... |
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Prevention and treatment of postmenopausal osteoporosis
J. Steroid Biochem. Mol. Biol. 142 , 155-70, (2014) • ET/HT is first choice for osteoporosis prevention in women <10 years of menopause. • Bisphosphonates is first choice for osteoporosis in older women ≥60 years. • SERMs are an alternative for women who cannot take bisphosphonates or HT/ET. |
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Noncovalent PEGylation: different effects of dansyl-, L-tryptophan-, phenylbutylamino-, benzyl- and cholesteryl-PEGs on the aggregation of salmon calcitonin and lysozyme.
J. Pharm. Sci. 101(6) , 1995-2008, (2012) Protein aggregation is a major instability that can occur during all stages of protein drug production and development. Protein aggregates may compromise the safety and efficacy of the final protein formulation. In this paper, various new excipients [phenylbu... |
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Design and evaluation of inhalable chitosan-modified poly (DL-lactic-co-glycolic acid) nanocomposite particles.
Eur. J. Pharm. Sci. 47(1) , 235-43, (2012) The aim of this study was to investigate two types of chitosan-modified poly (DL-lactic-co-glycolic acid) (PLGA) nanocomposite particles containing salmon calcitonin for pulmonary delivery, which were obtained using spray drying fluidized bed granulation (Agg... |
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The inhibitory effect of salmon calcitonin on tri-iodothyronine induction of early hypertrophy in articular cartilage.
PLoS ONE 7(6) , e40081, (2012) Salmon calcitonin has chondroprotective effect both in vitro and in vivo, and is therefore being tested as a candidate drug for cartilage degenerative diseases. Recent studies have indicated that different chondrocyte phenotypes may express the calcitonin rec... |
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Transdermal absorption and stability enhancement of salmon calcitonin by Tat peptide.
Drug Dev. Ind. Pharm. 39(4) , 520-5, (2013) Highly organized structure of stratum corneum (SC) is the major barrier of the delivery of macromolecules such as proteins and peptides across the skin. Recently, cell penetrating peptides (CPPs) such as HIV1-trans-activating transcriptional (Tat) have been u... |
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Metal ions as cofactors for aggregation of therapeutic peptide salmon calcitonin.
Inorg. Chem. 51(10) , 5642-50, (2012) The effects of multivalent metal ions (Cu(2+)/Zn(2+)/Al(3+)) on the aggregation of salmon calcitonin (sCT)--a therapeutic peptide used worldwide in the treatment of osteoporosis and Paget's disease--have been studied in vitro using NMR (both solution state an... |
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Quantitation of polypeptides (glucagon and salmon calcitonin) in plasma samples by 'high resolution' on a triple quadrupole mass spectrometer.
Bioanalysis 4(6) , 685-91, (2012) Bioanalysis of large molecules can be challenging on LC-MS/MS due to multiply charged and endogenous interferences. While high sensitivity triple quadrupole systems (QqQ) have been commercialized recently, high-resolution MS (HRMS) systems are also available.... |