Salmon Calcitonin Acetate structure
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Common Name | Salmon Calcitonin Acetate | ||
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CAS Number | 47931-85-1 | Molecular Weight | 3431.853 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C145H240N44O48S2 | Melting Point | N/A | |
MSDS | USA | Flash Point | N/A |
Use of Salmon Calcitonin AcetateCalcitonin salmon, a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption. Sequence: Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2(Disulfide bridge: Cys1-Cys7). |
Name | calcitonin |
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Synonym | More Synonyms |
Description | Calcitonin salmon, a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption. Sequence: Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2(Disulfide bridge: Cys1-Cys7). |
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Related Catalog | |
Target |
Amylin, Calcitonin receptor[1]. |
In Vivo | Oral Calcitonin salmon treatment dose-dependently attenuates fasting and non-fasted hyperglycaemia during the intervention period. At the end of the study period, oral Calcitonin salmon treatment by dose decreases diabetic hyperglycaemia by ~9 mM and reduces HbA1c levels by 1.7%. Furthermore, a pronounced reduction in glucose excursions is dose-dependently observed for oral Calcitonin salmon treatment during oral glucose tolerance test. In addition, oral Calcitonin salmon treatment sustains hyperinsulinaemia and attenuates hyperglucagonaemia and hypersecretion of total glucagon-like peptide-1 predominantly in the basal state. Lastly, oral Calcitonin salmon treatment dose-dependently improves pancreatic beta-cell function and beta-cell area at study end[1]. |
Animal Admin | Rats[1] Male ZDF rats are treated with oral Calcitonin salmon (sCT: 0.5, 1.0 or 2 mg/kg) or oral vehicle twice daily from age 8 to 18 weeks. Zucker lean rats serve as control group. Fasting and non-fasted blood glucose, glycosylated haemoglobin (HbA1c) and levels of pancreas and incretin hormones are determined. Oral glucose tolerance test and i.p. glucose tolerance test were compared, and beta-cell area and function were evaluated[1]. |
References |
Density | 1.5±0.1 g/cm3 |
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Molecular Formula | C145H240N44O48S2 |
Molecular Weight | 3431.853 |
Exact Mass | 3429.713379 |
PSA | 1558.81000 |
LogP | -12.48 |
Index of Refraction | 1.677 |
Storage condition | −20°C |
Water Solubility | 0.05 M acetic acid: 1 mg/mL, clear, colorless |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier.
Biomaterials 33(34) , 8881-92, (2012) The objective of the present study was to demonstrate the effect of polyanionic copolymer mPEG-grafted-alginic acid (mPEG-g-AA)-based polyion complex (PIC) micelles on enhancing the oral absorption of... |
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[Osteoporotic fractures: not only in females].
Rev. Med. Suisse 10(424) , 767-8, (2014)
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Decline in calcitonin receptor expression in osteocytes with age.
J. Endocrinol. 221(2) , 181-91, (2014) We have previously shown that co-administration of the transient osteoclast inhibitor, salmon calcitonin (sCT), blunts the anabolic effect of parathyroid hormone (PTH) in young rats and increases oste... |
MFCD00133859 |
tz-ct |
Calcitoran |
Calcitoninsalmon |
Thyrocalcitonin |
calcimar |
Calcitonin salmon |
Calcitonin |
SALMON |
Salmon Calcium |
Salmon Calcitonin Acetate |
EINECS 256-342-8 |
Salmotonin |
Salcitonin |
Salcatonin |
cibacalcin |
Salmon Calcitonin |
Calcitonin (salmon) |
CYS-SER-ASN-LEU-SER-THR-CYS-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-GLY-THR-PRO-NH2(DISULFIDE BRIDGE CYS1-CYS7) |