Fmoc-Cys(Trt)-OH
Fmoc-Cys(Trt)-OH structure
|
Common Name | Fmoc-Cys(Trt)-OH | ||
|---|---|---|---|---|
| CAS Number | 103213-32-7 | Molecular Weight | 585.711 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 763.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C37H31NO4S | Melting Point | 170-173 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 415.5±32.9 °C | |
|
Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies.
FASEB J. 29 , 1763-79, (2015) Humanized hapten-binding IgGs were designed with an accessible cysteine close to their binding pockets, for specific covalent payload attachment. Individual analyses of known structures of digoxigenin (Dig)- and fluorescein (Fluo) binding antibodies and a new... |
|
|
Collagen-mimetic peptide-modifiable hydrogels for articular cartilage regeneration.
Biomaterials 54 , 213-25, (2015) Regenerative medicine strategies for restoring articular cartilage face significant challenges to recreate the complex and dynamic biochemical and biomechanical functions of native tissues. As an approach to recapitulate the complexity of the extracellular ma... |
|
|
Tumor-selective peptide-carrier delivery of Paclitaxel increases in vivo activity of the drug.
Sci. Rep. 5 , 17736, (2015) Taxanes are highly effective chemotherapeutic drugs against proliferating cancer and an established option in the standard treatment of ovarian and breast cancer. However, treatment with paclitaxel is associated with severe side effects, including sensory axo... |
|
|
Non-covalent photo-patterning of gelatin matrices using caged collagen mimetic peptides.
Macromol. Biosci. 15(1) , 52-62, (2015) To address the downside of conventional photo-patterning which can alter the chemical composition of protein scaffolds, we developed a non-covalent photo-patterning strategy for gelatin (denatured collagen) hydrogels that utilizes UV activated triple helical ... |
|
|
Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.
Bioorg. Med. Chem. Lett. 17 , 3921-4, (2007) Inhibition of Eg5 represents a novel approach for the treatment of cancer. Here, we report the synthesis and structure-activity relationship of S-trityl-L-cysteine (STLC) derivatives as Eg5 inhibitors. Some of these derivatives such as 4f demonstrated enhance... |
|
|
Optimal structural design of mannosylated nanocarriers for macrophage targeting.
J. Control. Release 194 , 341-9, (2014) Macrophages are involved in a number of diseases, such as HIV infection/AIDS, tuberculosis, tumor development and atherosclerosis. Macrophages possess several cell surface receptors (e.g., the mannose receptor, MR) that may serve as drug delivery cellular por... |
|
|
The investigation of Fmoc-cysteine derivatives in solid phase peptide synthesis.
Pept. Res. 2(1) , 147-52, (1989) Fmoc-Cys(t-Bu)-OH, Fmoc-Cys(Acm)-OH, and Fmoc-Cys(Trt)-OH exhibit excellent synthesis characteristics when used in Fmoc solid phase peptide synthesis on the Applied Biosystems Model 431A peptide synthesizer. The actual 5% scavenger mixture will vary according... |
|
|
Inhibition of Kallikrein-Related Peptidases 7 and 5 by Grafting Serpin Reactive-Center Loop Sequences onto Sunflower Trypsin Inhibitor-1 (SFTI-1).
ChemBioChem. 17 , 719-26, (2016) Serpin proteins irreversibly inhibit serine proteases, but only a small part of the serpin reactive-center loop (RCL) is responsible for the initial protein-protein interaction (PPI). To develop peptidic protease inhibitors, kallikrein-related peptidases 7 (K... |