4-Fluoro-3-nitrobenzoic acid
4-Fluoro-3-nitrobenzoic acid structure
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Common Name | 4-Fluoro-3-nitrobenzoic acid | ||
|---|---|---|---|---|
| CAS Number | 453-71-4 | Molecular Weight | 185.109 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 356.9±27.0 °C at 760 mmHg | |
| Molecular Formula | C7H4FNO4 | Melting Point | 123-126 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 169.6±23.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Solid phase synthesis of functionalized biaryl ethers: versatile scaffolds for combinatorial chemistry.
Mol. Divers. 3(2) , 117-20, (1997) 4-Fluoro-3-nitrobenzoic acid attached to a solid support was shown to react under mild conditions with a wide range of functionalized phenols to yield, after cleavage, the corresponding biaryl ethers in excellent purity. In a similar fashion, biaryl thioether... |
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Combinatorial synthesis of biheterocyclic benzimidazoles by microwave irradiation.
Comb. Chem. High Throughput Screen 7(3) , 251-5, (2004) Liquid phasel synthesis of biheterocyclic benzimidazoles by controlled microwave irradiation was investigated. Polymer immobilized o-phenylenediamines was synthesized under microwave irradiation. The resulting PEG bound diamines was N-acylated with 4-fluoro-3... |
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Reagents for the preparation of chromophorically labeled polyethylene glycol-protein conjugates.
Anal. Biochem. 210(2) , 258-61, (1993) We have developed a new class of reagents (2) for the covalent attachment of polyethylene glycol to proteins. These reagents (2) are the monomethoxypolyethylene glycol esters of 4-fluoro-3-nitrobenzoic acid. The reaction of 2 with lysine epsilon-amino groups ... |
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Synthesis and evaluation of antimycobacterial activity of new benzimidazole aminoesters.
Eur. J. Med. Chem. , doi:10.1016/j.ejmech.2013.06.025, (2013) A total of 51 novel benzimidazoles were synthesized by a 4-step reaction starting from basic compound 4-fluoro-3-nitrobenzoic acid under relatively mild reaction conditions. The structure of the novel benzimidazoles was confirmed by mass spectra as well as (1... |
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Regioselective, unconventional Pictet-Spengler cyclization strategy toward the synthesis of benzimidazole-linked imidazoquinoxalines on a soluble polymer support.
Chem. Asian J. 6(6) , 1557-65, (2011) A novel strategy for an unconventional Pictet-Spengler reaction has been developed for the regioselective cyclization of the imidazole ring system at the C2 position. The developed strategy was utilized to develop a diversity-oriented parallel synthesis for b... |
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Parallel solid-phase synthesis of trisubstituted triazinobenzimidazolediones.
J. Comb. Chem. 4(4) , 345-51, (2002) An efficient method for the solid-phase synthesis of trisubstituted [1,3,5]triazino[1,2-a]benzimidazole-2,4(3H,10H)-diones from resin-bound amino acids is described. N-acylation of the primary amine of a resin-bound amino acid with 4-fluoro-3-nitrobenzoic aci... |
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Synthesis, characterization, and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors.
Bioorg. Chem. 49 , 33-9, (2013) Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structure were synthesized by a four-step reaction pathway starting from 4-fluoro-3-nitrobenzoic acid as the basic compound. The structur... |