α-Fluoro-β-alanine
α-Fluoro-β-alanine structure
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Common Name | α-Fluoro-β-alanine | ||
|---|---|---|---|---|
| CAS Number | 3821-81-6 | Molecular Weight | 107.08400 | |
| Density | 1.302g/cm3 | Boiling Point | 264.5ºC at 760 mmHg | |
| Molecular Formula | C3H6FNO2 | Melting Point | 222ºC | |
| MSDS | Chinese USA | Flash Point | 113.8ºC | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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beta-alanine and alpha-fluoro-beta-alanine concentrative transport in rat hepatocytes is mediated by GABA transporter GAT-2.
Am. J. Physiol. 276(1 Pt 1) , G206-10, (1999) Studies on the compartmentalization of uridine catabolic metabolism in liver have indicated accumulation of beta-alanine as well as alpha-fluoro-beta-alanine (FbetaAL) for 5-fluorouracil in the hepatocytes. Using preparations of rat hepatocytes we were able t... |
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Proton-decoupled 19F spectroscopy of 5-FU catabolites in human liver.
Magn. Reson. Med. 37(3) , 321-6, (1997) An RF network and a dual-tuned surface coil are described for obtaining proton-decoupled, NOE enhanced 19F spectra from a whole body clinical imager operating at 1.5 Tesia. The network removes 19F frequency noise from the decoupler transmitter, and prevents p... |
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The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(13-14) , 915-20, (2011) 5-Fluoro-2'-deoxyuridine (floxuridine, 5-FdUrd) and 5-fluorouracil (5-FU) are widely used for the treatment of colorectal cancers. The mechanisms of action of 5-FdUrd and 5-FU, as well as the biochemical pathway responsible for their metabolism, are well unde... |
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Biochemical modulation of the catabolism and tissue uptake of the anticancer drug 5-fluorouracil by 5-bromovinyluracil: assessment with metabolic (19)F MR imaging.
Magn. Reson. Med. 42(5) , 936-43, (1999) Using chemical shift-selective (19)F magnetic resonance (MR) imaging, we investigated the biomodulating action of 5-bromovinyluracil (BVU) on the degradation of the anticancer drug 5-fluorouracil (5-FU) to its major catabolite alpha-fluoro-beta-alanine (FBAL)... |
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Alternative pharmacokinetics of S-1 components, 5-fluorouracil, dihydrofluorouracil and alpha-fluoro-beta-alanine after oral administration of S-1 following total gastrectomy.
Cancer Sci. 98(10) , 1604-8, (2007) We studied whether total gastrectomy for gastric cancer would affect the pharmacokinetics of 5-fluorouracil (5-FU) and its degradation products, such as dihydrouracil (FUH(2)) and alpha-fluoro-beta-alanine (FBAL), after oral administration of the fluorouracil... |
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Assay of urinary alpha-fluoro-beta-alanine by gas chromatography-mass spectrometry for the biological monitoring of occupational exposure to 5-fluorouracil in oncology nurses and pharmacy technicians.
Biomed. Chromatogr. 20(3) , 257-66, (2006) The validation of an analytical method for the measurement of the unnatural amino acid alpha-fluoro-beta-alanine (AFBA), the main metabolite of the antineoplastic drug 5-fluorouracil (5FU), in urine for the biological monitoring of the exposure of hospital wo... |
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Superiority of hepatic arterial infusion in preventing catabolism of 5-FU compared with portal vein infusion revealed by an in vivo 19F NMR study.
Cancer Chemother. Pharmacol. 42(4) , 341-4, (1998) The aim of this study was to identify the route of administration of 5-FU with the greatest pharmacological advantage in a rat model using non-invasive in vivo 19F nuclear magnetic resonance (NMR) spectroscopy.5-FU (50 mg/kg) was administered to anesthetized ... |
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Validation of an isocratic HPLC method to detect 2-fluoro-beta-alanine for the analysis of dihydropyrimidine dehydrogenase activity.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(21) , 1889-92, (2010) The efficacy of the chemotherapeutic drug 5'-fluorouracil is reduced by catabolism to 2'-fluoro-beta-alanine (FBAL), a three-step reaction in which dihydropyrimidine dehydrogenase (DPD) catalyzes the rate-limiting step. To study in vitro DPD activity, we deve... |
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Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
Anticancer Drugs 15(10) , 969-74, (2004) Capecitabine (Xeloda) is a very active oral fluoropyrimidine (colon and breast cancers) whose clinical use is complicated by the presence of hand-foot syndrome (HFS). This cutaneous toxicity is less frequently encountered with other oral fluoropyrimidines con... |
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Pharmacokinetic study of S-1.
Int. J. Clin. Pharmacol. Ther. 47(1) , 65-7, (2009)
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