Perhexiline maleate
Perhexiline maleate structure
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Common Name | Perhexiline maleate | ||
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| CAS Number | 6724-53-4 | Molecular Weight | 393.56000 | |
| Density | N/A | Boiling Point | 574.1ºC at 760 mmHg | |
| Molecular Formula | C23H39NO4 | Melting Point | 181-183ºC | |
| MSDS | Chinese USA | Flash Point | 301ºC | |
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Torsade de pointes associated with perhexiline maleate therapy.
Aust. N. Z. J. Med. 20(6) , 818-20, (1990) Multiform ventricular tachycardia (torsade de pointes) is a recognised proarrhythmic effect of drugs which prolong the QT interval. A case is now described for the first time where torsade de pointes occurred with the administration of the anti-anginal agent ... |
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Further studies on the pharmacokinetics of perhexiline maleate in humans.
Xenobiotica 16(1) , 63-8, (1986) We have performed single-dose pharmacokinetic studies on perhexiline in eight young volunteers, each given 300 mg of Pexid orally, using an h.p.l.c. method for the separation and quantification of the drug and its monohydroxy metabolites in plasma and urine. ... |
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Stimulatory effect of perhexiline maleate on the basal and LHRH-stimulated luteinizing hormone release from rat pituitary cell aggregates in vitro.
Res. Commun. Mol. Pathol. Pharmacol. 87(2) , 115-23, (1995) Perhexiline maleate (PM) is an anti-anginal agent of amphiphilic character involved in lipidosis disorders. Experiments were carried out to study PM action on LH release from rat anterior pituitary cell aggregates. PM caused significant and dose-dependent inc... |
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A case series of concomitant treatment of perhexiline with amiodarone.
Ther. Drug Monit. 34(2) , 227-31, (2012) Concomitant treatment with amiodarone and perhsexiline has been considered to be relatively contraindicated because of the hypothetical risk of potentiated adverse effects mediated by additive inhibition of carnitine palmitoyl transferase 1.To study the preva... |
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Impairment of sulfobromophthalein biliary excretion and inhibition of glutathione S-transferase activity induced by perhexiline maleate in rats.
Biochem. Pharmacol. 37(18) , 3461-5, (1988) The effect of the antianginal agent perhexiline maleate (160 mg/kg i.g., daily for 4 days) on the biliary excretion of sulfobromophthalein (BSP) and BSP-glutathione and the hepatic activity of glutathione S-transferases was investigated in Wistar rats. Perhex... |
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Interactions of perhexiline maleate and arylalkylamine derivatives with cytochrome P-450 and in-vitro hydroxylation.
Biochem. Pharmacol. 35(14) , 2301-7, (1986) In order to find a substitute for perhexiline maleate, an antiangina drug, for which several side effects due to poor hydroxylation have been reported, an arylalkylamine series with antianginal properties has been synthesized. The aim of the present work was ... |
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Therapeutic monitoring of the anti-anginal drug perhexiline maleate.
Ann. Clin. Biochem. 22 ( Pt 6) , 614-7, (1985) Patients taking oral doses of perhexiline maleate have been examined. Measurement of serum perhexiline concentrations established that different dose requirements between patients were necessary due to the different doses at which drug saturation was achieved... |
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Leustroducsin B activates nuclear factor-kappaB via the acidic sphingomyelinase pathway in human bone marrow-derived stromal cell line KM-102.
J. Interferon Cytokine Res. 22(3) , 343-50, (2002) The novel colony-stimulating factor (CSF) inducer leustroducsin B (LSN-B), which was isolated from Streptomyces platensis, has been shown to have potent cytokine-inducing activities in clonal human bone marrow-derived stromal cell line KM-102 and in primary h... |
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The effects of perhexiline maleate on low density lipoprotein processing and cholesterol metabolism in cultured human fibroblasts.
Eur. J. Clin. Pharmacol. 34(2) , 195-9, (1988) The effects of perhexiline maleate (PM, Pexid) on low density lipoprotein (LDL) processing and cholesterol metabolism were investigated after a 24 h pretreatment with the drug. Perhexiline maleate increased LDL uptake in the range 10(-6) to 10(-5) M (180% of ... |
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Perhexiline maleate-induced hepatitis.
Hepatogastroenterology. 38(4) , 314-6, (1991) We report on a case of perhexiline maleate-induced hepatitis secondary to a long-term administration of recommended daily dosages of 300 mg. The patient had a spectacular weight loss of 29 kg. He developed hepatitis, which subsided after drug withdrawal. Our ... |