Betahistine
Betahistine structure
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Common Name | Betahistine | ||
|---|---|---|---|---|
| CAS Number | 5638-76-6 | Molecular Weight | 136.194 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 210.9±15.0 °C at 760 mmHg | |
| Molecular Formula | C8H12N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 96.7±0.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Development of novel sustained release matrix pellets of betahistine dihydrochloride: effect of lipophilic surfactants and co-surfactants.
Pharm. Dev. Technol. 17(5) , 583-93, (2012) Sustained release matrix pellets of the freely water soluble drug, betahistine dihydrochloride (BH), were prepared using freeze pelletization technique. Different waxes and lipids (cetyl alcohol, beeswax, glyceryl tripalmitate (GTP) and glyceryl tristearate) ... |
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Comparison of the therapeutic efficacy of a fixed low-dose combination of cinnarizine and dimenhydrinate with betahistine in vestibular neuritis: a randomized, double-blind, non-inferiority study.
Clin. Drug Investig. 32(6) , 387-99, (2012) Vestibular neuritis (VN) is a strongly disabling disease of the peripheral vestibular system. Rapid and effective relief of symptoms is important to allow patients to promptly return to normal physical activity.The aim of this prospective, randomized, double-... |
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Betahistine or Cinnarizine for treatment of Meniere's disease.
Med. Arh. 66(6) , 396-8, (2012) Meniere's disease is a condition with sudden attacks of vertigo with nausea and vomiting accompanied by loss of hearing and buzzing sensation in the ears, most commonly unilateral. The exact cause of the disease is unknown. Betahistine is the analogue of hist... |
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Vestibular rehabilitation with virtual reality in Ménière's disease.
Braz. J. Otorhinolaryngol. 79(3) , 366-74, (2013) Virtual reality technology can provide a wide range of sensory stimuli to generate conflicts of varying degrees of complexity in a safe environment.To verify the effect of a virtual realitybased balance rehabilitation program for patients with Menière's disea... |
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The effects of betahistine in addition to epley maneuver in posterior canal benign paroxysmal positional vertigo.
Otolaryngol. Head Neck Surg. 146(1) , 104-8, (2012) The purpose of this study is to evaluate the effects of betahistine in addition to Epley maneuver on the quality of life of patients with posterior semicircular canal benign paroxysmal positional vertigo (BPPV) of the canalithiasis type.Double-blind, randomiz... |
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Menière-like syndrome in Camurati-Engelmann disease.
Isr. Med. Assoc. J. 15(7) , 390-1, (2013)
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Benign paroxysmal positional vertigo (BPPV): influence of pharmacotherapy and rehabilitation therapy on patients' recovery rate and life quality.
NeuroRehabilitation 31(4) , 435-41, (2012) This prospective clinical study includes 96 BPPV patients with the results of DHI testing ≥ 40 points. They were segregated to be taken into this study and randomly divided into two therapy groups: 48 patients in Group I were treated pharmacotherapeutically w... |
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Bayesian model selection techniques as decision support for shaping a statistical analysis plan of a clinical trial: an example from a vertigo phase III study with longitudinal count data as primary endpoint.
BMC Med. Res. Methodol. 12 , 137, (2012) A statistical analysis plan (SAP) is a critical link between how a clinical trial is conducted and the clinical study report. To secure objective study results, regulatory bodies expect that the SAP will meet requirements in pre-specifying inferential analyse... |
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Involvement of histamine receptors in SAPK/JNK phosphorylation
Int. Immunopharmacol. 13(2) , 190-6, (2012) Histamine is a mediator of inflammation in allergic disease and asthma. Stress activated protein kinases/c-jun N-terminal kinases (SAPK/JNK) are involved in asthma. This study examined the role of histamine receptors on the phosphorylation of SAPK/JNK in sple... |
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Duplicate internal auditory canals with facial and vestibulocochlear nerve dysfunction.
J. Laryngol. Otol. 126(1) , 66-71, (2012) We report an extremely rare case of duplication of the internal auditory canal associated with dysfunction of both the facial and vestibulocochlear nerves. We also review the literature regarding the integrity of the facial and vestibulocochlear nerves in suc... |