Phenol red
Phenol red structure
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Common Name | Phenol red | ||
|---|---|---|---|---|
| CAS Number | 143-74-8 | Molecular Weight | 354.376 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 562.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C19H14O5S | Melting Point | 300 °C | |
| MSDS | Chinese USA | Flash Point | 294.2±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion, and metastasis.
Cancer Res. 75(6) , 1102-12, (2015) The translation initiation factor eIF4E is an oncogene that is commonly overexpressed in primary breast cancers and metastases. In this article, we report that a pharmacologic inhibitor of eIF4E function, ribavirin, safely and potently suppresses breast tumor... |
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Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.
Drug Des. Devel. Ther. 9 , 1555-84, (2015) Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN8237) is a selective Aurora kinase A inhibitor that displays a... |
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Methionine oxidation accelerates the aggregation and enhances the neurotoxicity of the D178N variant of the human prion protein.
Biochim. Biophys. Acta 1842(12 Pt A) , 2345-56, (2014) The D178N mutation of the prion protein (PrP) results in the hereditary prion disease fatal familial insomnia (FFI). Little is known regarding the effects of methionine oxidation on the pathogenesis of D178N-associated FFI. In the present study, we found that... |
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Novel in silico-designed estradiol analogues are cytotoxic to a multidrug-resistant cell line at nanomolar concentrations.
Cancer Chemother. Pharmacol. 75(2) , 431-7, (2015) 2-Methoxyestradiol (2ME) is a promising anti-cancer agent that disrupts the integrity and dynamics of the spindle network. In order to overcome the pharmacokinetic constraints of this compound, a panel of sulphamoylated estradiol analogues were in silico-desi... |
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A precisely substituted benzopyran targets androgen refractory prostate cancer cells through selective modulation of estrogen receptors.
Toxicol. Appl. Pharmacol. 283(3) , 187-97, (2015) Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against ... |
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Preservation of the structure of enzymatically-degraded bovine vitreous using synthetic proteoglycan mimics.
Invest. Ophthalmol. Vis. Sci. 55(12) , 8153-62, (2014) Vitreous liquefaction and subsequent posterior vitreous detachment can lead to several sight-threatening diseases, including retinal detachment, macular hole and macular traction syndrome, nuclear cataracts, and possibly, open-angle glaucoma. In this study, w... |
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Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells.
Oncotarget 5(13) , 4765-78, (2014) Although non-small cell lung cancer (NSCLC) patients with EGFR mutation positive (EGFR M+) tumors initially respond well to EGFR tyrosine kinase inhibitor (TKI) monotherapy, the responses are usually incomplete. In this study we show that AKT inhibition, most... |
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Galectin-3 contributes to luteolysis by binding to Beta 1 integrin in the bovine corpus luteum.
Biol. Reprod. 91(1) , 2, (2014) Luteolysis is characterized by a reduction in progesterone (P4) production and tissue degeneration in the corpus luteum (CL). One of major events during luteolysis is luteal cell death. Galectin-3, a ubiquitously expressed protein involved in many cellular pr... |
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Oxidants induce a corticosteroid-insensitive phosphorylation of histone 3 at serine 10 in monocytes.
PLoS ONE 10(4) , e0124961, (2015) Oxidative stress enhances inflammation and reduces the effectiveness of corticosteroids, but the inflammatory signalling pathways induced by oxidants remain ill-defined. Phosphorylation of histone 3 at serine 10 (H3-Pser10) marks out a subset of inflammatory ... |
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Embryonic development and maternal regulation of murine circadian clock function.
Chronobiol. Int. 32(3) , 416-27, (2015) The importance of circadian clocks in the regulation of adult physiology in mammals is well established. In contrast, the ontogenesis of the circadian system and its role in embryonic development are still poorly understood. Although there is experimental evi... |