3-Indoleacetic acid

3-Indoleacetic acid Structure
3-Indoleacetic acid structure
Common Name 3-Indoleacetic acid
CAS Number 87-51-4 Molecular Weight 175.184
Density 1.4±0.1 g/cm3 Boiling Point 415.0±20.0 °C at 760 mmHg
Molecular Formula C10H9NO2 Melting Point 165-169 °C(lit.)
MSDS Chinese USA Flash Point 204.8±21.8 °C

A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus.

Vet. Parasitol. 207(3-4) , 266-75, (2015)

The mechanisms involved in anthelmintic resistance (AR) are complex but a greater understanding of AR management is essential for effective and sustainable control of parasitic helminth worms in livestock. Current tests to measure AR are time consuming and ca...

FCA mediates thermal adaptation of stem growth by attenuating auxin action in Arabidopsis.

Nat. Commun. 5 , 5473, (2014)

Global warming is predicted to profoundly affect plant distribution and crop yield in the near future. Higher ambient temperature can influence diverse aspects of plant growth and development. In Arabidopsis, the basic helix-loop-helix transcription factor Ph...

Potential predictive plasma biomarkers for cervical cancer by 2D-DIGE proteomics and Ingenuity Pathway Analysis.

Tumour Biol. 36(3) , 1711-20, (2015)

The current methods available for screening and detecting cervical squamous cell carcinoma (CSCC) have insufficient sensitivity and specificity. As a result, many patients suffered from erroneous and missed diagnosis. Because CSCC is usually asymptomatic at p...

High abundant protein removal from rodent blood for biomarker discovery.

Biochem. Biophys. Res. Commun. 455(1-2) , 84-9, (2015)

In order to realize the goal of stratified and/or personalized medicine in the clinic, significant advances in the field of biomarker discovery are necessary. Adding to the abundance of nucleic acid biomarkers being characterized, additional protein biomarker...

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.

Nat. Cell Biol. 17 , 782-92, (2015)

The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing. Mitochondria communicate with nuclei through retrograde signalling pathways t...

Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components.

J. Nanobiotechnology 13 , 84, (2015)

Gold nanoparticles (AuNPs) are a popular choice for use in medical and biomedical research applications. With suitable functionalisation AuNPs can be applied in drug delivery systems, or can aid in disease diagnosis. One such functionalisation is with chitosa...

Mitogen-Activated Protein Kinase 6 and Ethylene and Auxin Signaling Pathways Are Involved in Arabidopsis Root-System Architecture Alterations by Trichoderma atroviride.

Mol. Plant Microbe Interact. 28 , 701-10, (2015)

Trichoderma atroviride is a symbiotic fungus that interacts with roots and stimulates plant growth and defense. Here, we show that Arabidopsis seedlings cocultivated with T. atroviride have an altered root architecture and greater biomass compared with axenic...

Phosphoproteomic analysis of the highly-metastatic hepatocellular carcinoma cell line, MHCC97-H.

Int. J. Mol. Sci. 16(2) , 4209-25, (2015)

Invasion and metastasis of hepatocellular carcinoma (HCC) is a major cause for lethal liver cancer. Signaling pathways associated with cancer progression are frequently reconfigured by aberrant phosphorylation of key proteins. To capture the key phosphorylati...

Surface properties of nanocrystalline TiO2 coatings in relation to the in vitro plasma protein adsorption.

Biomed. Mater. 10 , 045012, (2015)

This study reports on the selective adsorption of whole plasma proteins on hydrothermally (HT) grown TiO2-anatase coatings and its dependence on the three main surface properties: surface charge, wettability and roughness. The influence of the photo-activatio...

Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics.

MAbs 7 , 881-90, (2015)

Regulatory agencies have recently recommended a Quality by Design (QbD) approach for the manufacturing of therapeutic molecules. A QbD strategy requires deep understanding at the molecular level of the attributes that are crucial for safety and efficacy and f...