Roscovitine (CYC202)
Roscovitine (CYC202) structure
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Common Name | Roscovitine (CYC202) | ||
|---|---|---|---|---|
| CAS Number | 186692-46-6 | Molecular Weight | 354.449 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 577.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C19H26N6O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 303.1±32.9 °C | |
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CDK5 is a major regulator of the tumor suppressor DLC1.
J. Cell Biol. 207(5) , 627-42, (2014) DLC1 is a tumor suppressor protein whose full activity depends on its presence at focal adhesions, its Rho-GTPase activating protein (Rho-GAP) function, and its ability to bind several ligands, including tensin and talin. However, the mechanisms that regulate... |
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Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress.
Oncotarget 6 , 13072-87, (2015) The therapeutic efficacy of nucleoside analogues, e.g. gemcitabine, against cancer cells can be augmented by inhibitors of checkpoint kinases, including Wee1, ATR, and Chk1. We have compared the chemosensitizing effect of these inhibitors in cells derived fro... |
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PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility.
Exp. Cell Res. 335 , 115-22, (2015) Podoplanin (PDPN) is a transmembrane glycoprotein that promotes tumor cell migration, invasion, and cancer metastasis. In fact, PDPN expression is induced in many types of cancer. Thus, PDPN has emerged as a functionally relevant cancer biomarker and chemothe... |
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Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B.
Sci. Rep. 5 , 16173, (2015) Numerical aberration of the centrosome results in chromosome missegregation, eventually leading to chromosomal instability, a hallmark of human tumor malignancy. Large tumor suppressors 1 and 2 (Lats1 and Lats2) are central kinases in the Hippo pathway and re... |
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An Endocytic Scaffolding Protein together with Synapsin Regulates Synaptic Vesicle Clustering in the Drosophila Neuromuscular Junction.
J. Neurosci. 35 , 14756-70, (2015) Many endocytic proteins accumulate in the reserve pool of synaptic vesicles (SVs) in synapses and relocalize to the endocytic periactive zone during neurotransmitter release. Currently little is known about their functions outside the periactive zone. Here we... |
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Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease.
J. Clin. Endocrinol. Metab. 100 , 2557-64, (2015) Cushing disease, due to pituitary corticotroph tumor ACTH hypersecretion, drives excess adrenal cortisol production with adverse morbidity and mortality. Loss of glucocorticoid negative feedback on the hypothalamic-pituitary-adrenal axis leads to autonomous t... |
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The early synthesis of p35 and activation of CDK5 in LPS-stimulated macrophages suppresses interleukin-10 production.
Sci. Signal. 8 , ra121, (2015) Interleukin-10 (IL-10) is an important anti-inflammatory cytokine that is produced primarily by macrophages. We investigated mechanisms by which the timing of IL-10 production was controlled in macrophages and found that cyclin-dependent kinase 5 (CDK5) activ... |
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Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders.
Molecular Neurodegeneration 6 , 67, (2011) Recent studies suggest that the pathogenic process in neurodegenerative disorders may disrupt mature neuronal circuitries and neurogenesis in the adult brain. Abnormal activation of CDK5 is associated with neurodegenerative disorders, and recently a critical ... |
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Involvement of cAMP in nerve growth factor-triggered p35/Cdk5 activation and differentiation in PC12 cells.
Am. J. Physiol. Cell Physiol. 299 , C516-27, (2010) The signaling mechanisms underlying cell differentiation have been extensively studied with the use of rat PC12 cells as a model system. Nerve growth factor (NGF) is a trophic factor inducing PC12 cell differentiation through the activation of the p35/cyclin-... |
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Maturation-associated Dbf4 expression is essential for mouse zygotic DNA replication.
Dev. Growth Differ. 56(9) , 625-39, (2014) Cdc7 is an S-phase-promoting kinase (SPK) that is required for the activation of replication initiation complex assembly because it phosphorylates the MCM protein complex serving as the replicative helicase in eukaryotic organisms. Cdc7 activity is undetectab... |