Flurbiprofen
Flurbiprofen structure
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Common Name | Flurbiprofen | ||
|---|---|---|---|---|
| CAS Number | 5104-49-4 | Molecular Weight | 244.261 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 376.2±30.0 °C at 760 mmHg | |
| Molecular Formula | C15H13FO2 | Melting Point | 110-112 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 181.3±24.6 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Combining structure- and ligand-based approaches to improve site of metabolism prediction in CYP2C9 substrates.
Pharm. Res. 32(3) , 986-1001, (2015) Predicting atoms in a potential drug compound that are susceptible to oxidation by cytochrome P450 (CYP) enzymes is of great interest to the pharmaceutical community. We aimed to develop a computational approach combining ligand- and structure-based design pr... |
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Evaluation of amino acid ester-based ionic liquids as buffer additives in CE for the separation of 2-arylpropionic acids nonsteroidal anti-inflammatory drugs.
Electrophoresis 35(18) , 2573-8, (2014) The aim of the present study is the CE performance evaluation for the separation of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs. In particular, the separation of indoprofen, carprofen, ketoprofen, ibuprofen, and flurbiprofen was obtained by supp... |
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A chiral separation strategy for acidic drugs in capillary electrochromatography using both chlorinated and nonchlorinated polysaccharide-based selectors.
Electrophoresis 35(19) , 2807-18, (2014) A generic chiral separation strategy for the analysis of acidic compounds in CEC is proposed in completion of an earlier defined strategy for nonacidic compounds. The screening step of this strategy uses a 45 mM ammonium formate (pH 2.9)/ACN (35/65, v/v) mobi... |
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Phenotyping of CYP450 in human liver microsomes using the cocktail approach.
Anal. Bioanal. Chem 406(20) , 4875-87, (2014) The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this study, a cocktail mixture was developed with eight CYP-spe... |
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Comparison of liquid chromatography and supercritical fluid chromatography coupled to compact single quadrupole mass spectrometer for targeted in vitro metabolism assay.
J. Chromatogr. A. 1371 , 244-56, (2014) The goal of this study was to evaluate the combination of powerful chromatographic methods and compact single quadrupole MS device for simple in vitro cytochrome P450 (CYP) inhibition assay, instead of more expensive triple quadrupole MS/MS detectors. For thi... |
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Determination of flurbiprofen in human plasma by gas chromatography with mass spectrometry and its pharmacokinetics.
J. AOAC Int. 97(4) , 1061-6, (2014) This paper describes a GCIMS method for the determination of flurbiprofen in human plasma. Flurbiprofen and internal standard ibuprofen were extracted from plasma by using a liquid-liquid extraction method. Derivatization was carried out using N-Methyl-N-(tri... |
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A new analytical method to determine non-steroidal anti-inflammatory drugs in surface water using in situ derivatization combined with ultrasound-assisted emulsification microextraction followed by gas chromatography-mass spectrometry.
Talanta 129 , 552-9, (2014) Because of the high stability and potential toxic effects of non-steroidal anti-inflammatory drugs (NSAIDs), it is important to closely monitor their concentrations in the environment using a sensitive analytical method. In this study, a simple, rapid, effici... |
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Evaluation of stationary phases packed with superficially porous particles for the analysis of pharmaceutical compounds using supercritical fluid chromatography.
J. Chromatogr. A. 1360 , 275-87, (2014) Superficially porous particles (SPP), or core shell particles, which consist of a non-porous silica core surrounded by a thin shell of porous silica, have gained popularity as a solid support for chromatography over the last decade. In the present study, five... |
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Factors influencing crystal growth rates from undercooled liquids of pharmaceutical compounds.
J. Phys. Chem. B 118(33) , 9974-82, (2014) Amorphous forms of drugs are increasingly being used to deliver poorly water-soluble compounds. Therefore, understanding the magnitude and origin of differences in crystallization kinetics is highly important. The goal of this study was to better understand t... |
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Synthesis and pharmacological evaluation of polyfunctional benzimidazole-NSAID chimeric molecules combining anti-inflammatory, immunomodulatory and antioxidant activities.
Arch. Pharm. Res. 37(11) , 1426-36, (2014) Polyfunctional compounds comprise a novel class of therapeutic agents for treatment of multifactorial diseases. The present study reports a series of benzimidazole-non-steroidal anti-inflammatory drugs (NSAIDs) conjugates (1-10) as novel polyfunctional compou... |