Itraconazole
Itraconazole structure
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Common Name | Itraconazole | ||
|---|---|---|---|---|
| CAS Number | 84625-61-6 | Molecular Weight | 705.633 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 850.0±75.0 °C at 760 mmHg | |
| Molecular Formula | C35H38Cl2N8O4 | Melting Point | 166°C | |
| MSDS | Chinese USA | Flash Point | 467.9±37.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.
Autophagy 10(7) , 1241-55, (2014) Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazole, a traditional antifungal drug, has been identified as a ... |
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Antifungal susceptibility and virulence attributes of animal-derived isolates of Candida parapsilosis complex.
J. Med. Microbiol. 63(Pt 11) , 1568-72, (2014) This study aimed to identify strains of the Candida parapsilosis complex isolated from animals, as well as to assess their in vitro antifungal susceptibility profile and in vitro production of virulence attributes. We used 28 isolates of C. parapsilosis sensu... |
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European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe.
Eur. J. Clin. Microbiol. Infect. Dis. 33(9) , 1623-30, (2014) In order to better understand the epidemiology of fusariosis in Europe, a survey collecting information on the clinical characteristics of the patients infected by Fusarium as well as on the infecting isolates was launched. A total of 76 cases of invasive fus... |
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Simultaneous determination of seven azole antifungal drugs in serum by ultra-high pressure liquid chromatography and diode array detection.
Acta Clin. Belg. 69(1) , 53-61, (2014) Azole antifungals are a group of fungistatic agents that can be administered orally or parenterally. The determination of the concentrations of these antifungals (miconazole, fluconazole, ketoconazole, posaconazole, voriconazole, itraconazole, and its major a... |
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Investigation of minor species Candida africana, Candida stellatoidea and Candida dubliniensis in the Candida albicans complex among Yaoundé (Cameroon) HIV-infected patients.
Mycoses 58(1) , 33-9, (2014) Minor species of the Candida albicans complex may cause overestimation of the epidemiology of C. albicans, and misidentifications could mask their implication in human pathology. Authors determined the occurrence of minor species of the C. albicans complex (C... |
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Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism.
J. Anal. Toxicol. 39 , 374-86, (2015) Opioid-related mortality rates have escalated. Drug interactions may increase blood concentrations of the opioid. We therefore used human liver microsomes (HLMs) and cDNA-expressed human cytochrome P450s (rCYPs) to study in vitro inhibition of buprenorphine m... |
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Electrochemical behavior of the antifungal agents itraconazole, posaconazole and ketoconazole at a glassy carbon electrode.
Pharmazie 70 , 374-8, (2015) The electrochemical behavior of the azole antifungal agents itraconazole, posaconazole and ketoconazole has been investigated at a glassy carbon working electrode using cyclic voltammetry. All measurements were carried out in a supporting electrolyte solution... |
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Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A.
Arch. Biochem. Biophys. 575 , 1-7, (2015) Streptomyces avermitilis contains 33 cytochrome P450 genes in its genome, many of which play important roles in the biosynthesis process of antimicrobial agents. Here, we characterized the biochemical function and structure of CYP107W1 from S. avermitilis, wh... |
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Heat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole.
Int. J. Pharm. 471(1-2) , 400-11, (2014) Itraconazole (ITR) is an antifungal drug with a limited bioavailability due to its poor aqueous solubility. In this study, ITR was used to investigate the impact of nanonisation and solid state change on drug's apparent solubility and dissolution. A bottom up... |
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Development and lyophilization of itraconazole loaded poly(butylcyanoacrylate) nanospheres as a drug delivery system.
Eur. J. Pharm. Sci. 78 , 121-31, (2015) Itraconazole is a poorly soluble drug which is used in the treatment of systemic fungal infections. However, there is little reported literature about itraconazole loaded delivery systems used for targeted delivery. Therefore, poly(butyl cyanoacrylate) nanosp... |