Voriconazole
Voriconazole structure
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Common Name | Voriconazole | ||
|---|---|---|---|---|
| CAS Number | 137234-62-9 | Molecular Weight | 349.31 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 508.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C16H14F3N5O | Melting Point | 127-130°C | |
| MSDS | Chinese USA | Flash Point | 261.4±32.9 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Antifungal susceptibility and virulence attributes of animal-derived isolates of Candida parapsilosis complex.
J. Med. Microbiol. 63(Pt 11) , 1568-72, (2014) This study aimed to identify strains of the Candida parapsilosis complex isolated from animals, as well as to assess their in vitro antifungal susceptibility profile and in vitro production of virulence attributes. We used 28 isolates of C. parapsilosis sensu... |
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European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe.
Eur. J. Clin. Microbiol. Infect. Dis. 33(9) , 1623-30, (2014) In order to better understand the epidemiology of fusariosis in Europe, a survey collecting information on the clinical characteristics of the patients infected by Fusarium as well as on the infecting isolates was launched. A total of 76 cases of invasive fus... |
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Simultaneous determination of seven azole antifungal drugs in serum by ultra-high pressure liquid chromatography and diode array detection.
Acta Clin. Belg. 69(1) , 53-61, (2014) Azole antifungals are a group of fungistatic agents that can be administered orally or parenterally. The determination of the concentrations of these antifungals (miconazole, fluconazole, ketoconazole, posaconazole, voriconazole, itraconazole, and its major a... |
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The calcineurin inhibitor cyclosporin A exhibits synergism with antifungals against Candida parapsilosis species complex.
J. Med. Microbiol. 63(Pt 7) , 936-44, (2014) Candida parapsilosis complex comprises three closely related species, C. parapsilosis sensu stricto, Candida metapsilosis and Candida orthopsilosis. In the last decade, antifungal resistance to azoles and caspofungin among C. parapsilosis sensu lato strains h... |
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Pharmacokinetic and Pharmacodynamic Properties of Oral Voriconazole in Patients with Invasive Fungal Infections.
Pharmacotherapy 35 , 797-804, (2015) To assess the pharmacokinetic and pharmacodynamic (PK/PD) properties of voriconazole and to investigate the relationship between PK/PD parameters and the efficacy of a fixed-dose oral regimen in the treatment of invasive fungal infections (IFIs).Prospective a... |
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Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids.
MBio 6 , e00647, (2015) Recent estimates suggest that >300 million people are afflicted by serious fungal infections worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of activity. Thus, there is an urgent need for the development of new antifunga... |
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Fungal Morphology, Iron Homeostasis, and Lipid Metabolism Regulated by a GATA Transcription Factor in Blastomyces dermatitidis.
PLoS Pathog. 11 , e1004959, (2015) In response to temperature, Blastomyces dermatitidis converts between yeast and mold forms. Knowledge of the mechanism(s) underlying this response to temperature remains limited. In B. dermatitidis, we identified a GATA transcription factor, SREB, important f... |
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ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence.
PLoS Pathog. 10(11) , e1004487, (2014) The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence. The latter phenotype is especially strik... |
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Mechanisms of azole resistance in Candida albicans clinical isolates from Shanghai, China.
Res. Microbiol. 166 , 153-61, (2015) This study was undertaken to characterize the mechanism(s) of azole resistance in clinical isolates of Candida albicans collected in Shanghai, China, focusing on the role of efflux pumps, target enzymes of fluconazole (Erg11), respiratory status and the ergos... |
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Efficacy and safety of antifungal additives in Optisol-GS corneal storage medium.
JAMA Ophthalmol. 132(7) , 832-7, (2014) Optisol-GS, the most common corneal storage medium in the United States, contains antibacterial but no antifungal supplementation. Most postkeratoplasty endophthalmitis and keratitis cases are now of a fungal origin.To assess the efficacy and safety of vorico... |