Potassium canrenoate
Potassium canrenoate structure
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Common Name | Potassium canrenoate | ||
|---|---|---|---|---|
| CAS Number | 2181-04-6 | Molecular Weight | 396.56200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H29KO4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Effect of the steroid K-canrenoate on hsp70 expression and tissue damage in transgenic Drosophila melanogaster (hsp70-lacZ) Bg9.
J. Insect Sci. 12 , 92, (2012) In the present study the effect of 0.1, 0.2, 0.4, 0.8, and 1.0 µL/mL of the steroid K-canrenoate was evaluated in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg(9) for 6, 24, and 48 hours of duration. The treatment of 0.1, 0.2, ... |
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Mineralocorticoids participate in the reduced vascular reactivity of pregnant rats.
Am. J. Physiol. Heart Circ. Physiol. 302(5) , H1195-201, (2012) The renin-angiotensin-aldosterone (RAA) system is markedly activated in pregnancy. We evaluated if mineralocorticoid receptors (MR), a major component of the RAA system, are involved in the reduced vascular reactivity associated with pregnancy. Canrenoate (MR... |
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Akt-mediated cardioprotective effects of aldosterone in type 2 diabetic mice.
FASEB J. 28(6) , 2430-40, (2014) Studies have shown that aldosterone would have angiogenic effects and therefore would be beneficial in the context of cardiovascular diseases. We thus investigated the potential involvement of aldosterone in triggering a cardiac angiogenic response in the con... |
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Differential effects of mineralocorticoid blockade on the hypothalamo-pituitary-adrenal axis in pregnant and nonpregnant ewes.
Am. J. Physiol. Endocrinol. Metab. 300(3) , E592-9, (2011) During pregnancy, plasma ACTH and cortisol are chronically increased; this appears to occur through a reset of hypothalamo-pituitary-adrenal (HPA) activity. We have hypothesized that differences in mineralocorticoid receptor activity in pregnancy may alter fe... |
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Population pharmacokinetic model of canrenone after intravenous administration of potassium canrenoate to paediatric patients.
Br. J. Clin. Pharmacol. 74(5) , 864-72, (2012) Little is known about the pharmacokinetics of potassium canrenoate/canrenone in paediatric patientsA population pharmacokinetic model has been developed to evaluate the pharmacokinetics of canrenone in paediatric patients who received potassium canrenoate as ... |
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Cardiac corticosteroid receptors mediate the enlargement of the ovine fetal heart induced by chronic increases in maternal cortisol.
J. Endocrinol. 198(2) , 419-27, (2008) Previous studies have demonstrated that modest, physiologically relevant increases in maternal cortisol in late gestation result in enlargement of the fetal heart. In this study, we investigated the role of mineralocorticoid receptor (MR) or glucocorticoid re... |
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Time-course reduction of renal function in rats on high sodium intake: acute reversal by potassium canrenoate.
Clin. Exp. Pharmacol. Physiol. 35(4) , 412-5, (2008) 1. Time course of renal alterations associated with long-term (since weaning) administration of a high sodium (HS, 8% NaCl) diet was assessed in Sprague-Dawley rats. Reversal by acute administration of the mineralocorticoid receptor antagonist, potassium canr... |
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Prenatal corticosteroid exposure alters early developmental seizures and behavior
Epilepsy Res. 95(1-2) , 9-19, (2011) In humans, corticosteroids are often administered prenatally to improve lung development in preterm neonates. Studies in exposed children as well as in children, whose mothers experienced significant stress during pregnancy indicate behavioral problems and po... |
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Menopause not aldosterone-to-renin ratio predicts blood pressure response to a mineralocorticoid receptor antagonist in primary care hypertensive patients.
Am. J. Hypertens. 21(9) , 976-82, (2008) It has been suggested that hypertensive patients with raised aldosterone-to-renin ratio (ARR) are specifically sensitive to mineralocorticoid receptor antagonists (MRAs). We have previously shown that patients with an elevated ARR are relatively frequent in t... |
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Effect of spironolactone, potassium canrenoate and their common metabolite canrenone on serum digoxin measurement by digoxin III, a new digoxin immunoassay.
Ther. Drug Monit. 30(6) , 744-7, (2008) Spironolactone and potassium canrenoate (aldosterone antagonist diuretics) are often used with digoxin in clinical practice. It has been well documented in the literature that spironolactone, potassium canrenoate, and their common metabolite canrenone cross-r... |