Neostigmine Methylsulfate
Neostigmine Methylsulfate structure
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Common Name | Neostigmine Methylsulfate | ||
|---|---|---|---|---|
| CAS Number | 51-60-5 | Molecular Weight | 334.389 | |
| Density | N/A | Boiling Point | 457ºC | |
| Molecular Formula | C13H22N2O6S | Melting Point | 175-177 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Chiral analysis of bambuterol, its intermediate and active drug in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 997 , 38-44, (2015) A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed for simultaneous chiral analysis of an antiasthma drug bambuterol, its key intermediate monocarbamate bambuterol and its active drug terbutaline in human plasma. A... |
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Simultaneous determination of bambuterol and its two major metabolites in human plasma by hydrophilic interaction ultra-performance liquid chromatography-tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 967 , 225-34, (2014) In this study, a rapid and sensitive hydrophilic interaction ultra-performance liquid chromatography-tandem mass spectrometry (HILIC-UPLC-MS/MS) method was developed for simultaneous determination of bambuterol and its two major metabolites monocarbamate bamb... |
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In vivo and in vitro effects of neostigmine on gastrointestinal tract motility of horses.
Am. J. Vet. Res. 74(4) , 579-88, (2013) To determine the response to neostigmine of the contractile activity of the jejunum and pelvic flexure and the effects of a continuous rate infusion (CRI) of neostigmine in horses.7 adult horses and tissue from 12 adult horses.A CRI of neostigmine (0.008 mg/k... |
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An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.
J. Biomol. Screen. 18(1) , 108-15, (2013) Organophosphates are a class of highly toxic chemicals that includes many pesticides and chemical weapons. Exposure to organophosphates, either through accidents or acts of terrorism, poses a significant risk to human health and safety. Existing antidotes, in... |
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Flow-through enzyme immobilized amperometric detector for the rapid screening of acetylcholinesterase inhibitors by flow injection analysis.
J. Pharm. Biomed. Anal. 102 , 267-75, (2015) A commercially available thin-layer flow-through amperometric detector, with the sensing block customized in an original design, was applied to the screening of drug compounds known as acetylcholinesterase (AChE) inhibitors. AChE from electric eel was covalen... |
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Global small bowel motility: assessment with dynamic MR imaging.
Radiology 269(2) , 443-50, (2013) To assess the repeatability in human volunteers of software-quantified small bowel motility captured with magnetic resonance (MR) imaging and to test the ability to detect changes in motility induced by pharmacologic agents.The study was approved by the Royal... |
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Premonitory signs and symptoms of envenoming by common krait (Bungarus caeruleus).
Trop. Doct. 44(2) , 82-5, (2014) Between January 2005 and August 2011 141 victims of krait bite poisoning were admitted to the general hospital at Mahad. Clinical signs and symptoms preceding the development of neuroparalysis were analyzed. Fifty-six percent of patients were male. A total of... |
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[Anticholinesterases; peripheral and central effects].
Masui. 62(1) , 19-26, (2013) Anticholinesterase, such as neostigmine, was used to be a standard drug at the end of surgery for reversal of nondepolarizing neuromuscular block. Neostigmine decreases the metabolism of acetylcholine (ACh) at the neuromuscular junction and allows its concent... |
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[Possible clinical potential in reverting muscular block with sugammadex in anaesthesia and surgery].
Ugeskr. Laeg. 175(7) , 428-32, (2013) Neuromuscular blockers (NMBs) provide good conditions for endotracheal intubation and surgery. NMBs have been associated with higher morbidity and mortality, mainly due to post-operative residual neuromuscular block. This may become history with the advent of... |
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Analgesic effect of intrathecal neostigmine combined with bupivacaine and fentanyl.
Afr. J. Med. Med. Sci. 41(2) , 231-7, (2012) The spinal route of analgesia has consolidated its place as a major modality in the management of both acute and chronic pain. The search for ideal additives to local anaesthetic agents to prolong the analgesic effects poses a challenge to the anaesthetists. ... |