Acrivastine
Acrivastine structure
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Common Name | Acrivastine | ||
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| CAS Number | 87848-99-5 | Molecular Weight | 348.438 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 555.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H24N2O2 | Melting Point | 55.5-59.5 °C(lit.) | |
| MSDS | USA | Flash Point | 289.5±30.1 °C | |
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Identification of novel functional inhibitors of acid sphingomyelinase.
PLoS ONE 6 , e23852, (2011) We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), therefore, can be potentially used to treat di... |
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Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatography.
J. Pharm. Biomed. Anal. 37(4) , 663-7, (2005) High-performance liquid chromatography (HPLC) was used for the simultaneous quantification of the H(1)-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride. Both compounds were detected at the wavelength of 214 nm. The influence of the... |
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Onset-of-action for antihistamine and decongestant combinations during an outdoor challenge.
Ann. Allergy Asthma Immunol. 84(4) , 451-9, (2000) Medications containing a combination antihistamine-decongestant are commonly used for allergic rhinitis yet onset-of-action comparisons for symptom relief after a single dose have not been performed.To determine the onset of symptom relief and efficacy of ant... |
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Efficacy of acrivastine plus pseudoephedrine for symptomatic relief of seasonal allergic rhinitis due to mountain cedar.
Ann. Allergy Asthma Immunol. 76(5) , 432-8, (1996) Acrivastine is a second-generation H1-antagonist chemically related to triprolidine, but more polar and with less central nervous system penetration than triprolidine.The efficacy of the antihistamine-decongestant combination product (Semprex-D capsules) cont... |
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Quantification of antihistamine acrivastine in plasma by solid-phase extraction and high-performance liquid chromatography.
J. Pharm. Biomed. Anal. 43(1) , 293-7, (2007) An automated solid-phase extraction method was developed for the determination of the H1-antihistamine acrivastine in plasma samples. Acrivastine was analyzed at the wavelength of 254 nm using a reversed-phase HPLC assay. Both extraction procedure and analyti... |
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Evaluation and comparison of five matrix excipients for the controlled release of acrivastine and pseudoephedrine.
Drug Dev. Ind. Pharm. 30(10) , 1009-17, (2004) For treatment of allergic rhinitis, acrivastine with pseudoephedrine in Semprex-D conventional capsules requires dosing every 6-8 hours. This study was designed to develop a controlled release matrix tablet of acrivastine and pseudoephedrine and evaluate 5 di... |
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Effects of acrivastine, loratadine and cetirizine on histamine-induced wheal and flare responses.
Clin. Exp. Dermatol. 24(5) , 407-11, (1999) It is accepted that studies evaluating histamine-induced wheal and flare reactions in the skin represent a simple and reliable method for demonstrating pharmacodynamic activity and pharmacokinetics of the H1-receptor antagonists. In this study, the effects of... |
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Efficacy of acrivastine with pseudoephedrine in treatment of allergic rhinitis due to ragweed.
Ann. Allergy Asthma Immunol. 76(2) , 204-8, (1996) Semprex-D capsules contain acrivastine 8 mg (a second generation H1-antagonist) plus pseudoephedrine HCl 60 mg and were developed to satisfy the needs of allergy suffers who prefer combination products designed to provide broader symptom relief. Approval of c... |
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Electrochemical behaviour and determination of acrivastine in pharmaceuticals and human urine.
J. Pharm. Biomed. Anal. 30(4) , 1215-22, (2002) The differential pulse polarography, DC-tast polarography and cyclic voltammetry behaviour of acrivastine was studied in Britton-Robinson buffer solutions (pH 2-11.7). In acidic media, a non-reversible diffusion controlled reduction process involving four ele... |
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Acrivastine: a review of its dermatopharmacology and clinical activity.
J. Int. Med. Res. 17 Suppl 2 , 28B-34B, (1989) The general human and skin pharmacology of acrivastine, its clinical utility and some important concepts of the use of H1-antihistamines in dermatology are discussed. The drug has potent H1-antihistamic activity yet a low sedative profile as compared with fir... |