Journal of Pharmaceutical and Biomedical Analysis 2002-11-07

Electrochemical behaviour and determination of acrivastine in pharmaceuticals and human urine.

R Fernández Torres, M Callejón Mochón, J C Jiménez Sánchez, M A Bello López, A Guiraúm Perez

Index: J. Pharm. Biomed. Anal. 30(4) , 1215-22, (2002)

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Abstract

The differential pulse polarography, DC-tast polarography and cyclic voltammetry behaviour of acrivastine was studied in Britton-Robinson buffer solutions (pH 2-11.7). In acidic media, a non-reversible diffusion controlled reduction process involving four electrons takes place. Two reduction waves appear at a E(1/2)=-0.6 and -0.99 V. The reduction mechanism is discussed. The linear relationship between peak current height and acrivastine concentration allowed the differential pulse polarographic determination of acrivastine over a wide concentration range, from 0.35 to 26.1 mg l(-1)at pH 2.5. The procedure was applied to determination of the drug in pharmaceutical formulations and human urine samples.