Clobetasol propionate
Clobetasol propionate structure
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Common Name | Clobetasol propionate | ||
|---|---|---|---|---|
| CAS Number | 25122-46-7 | Molecular Weight | 466.970 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 569.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C25H32ClFO5 | Melting Point | 195.5-197ºC | |
| MSDS | USA | Flash Point | 297.9±30.1 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Curcumin relieves TPA-induced Th1 inflammation in K14-VEGF transgenic mice.
Int. Immunopharmacol. 25(2) , 235-41, (2015) Curcumin has been confirmed to have anti-inflammatory properties in addition to the ability to decrease the expression of pro-inflammatory cytokines in keratinocytes. It was suggested that the interleukin-23 (IL-23)/IL-17A cytokine axis played a critical role... |
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Topical steroids for chronic wounds displaying abnormal inflammation.
Ann. R. Coll. Surg. Engl. 95(4) , 291-6, (2013) Chronic, non-healing wounds are often characterised by an excessive, and detrimental, inflammatory response. We review our experience of using a combined topical steroid, antibiotic and antifungal preparation in the treatment of chronic wounds displaying abno... |
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Impact of clobetasol propionate 0.05% spray on health-related quality of life in patients with plaque psoriasis.
Journal. of. Drugs in. Dermatology. 11(11) , 1348-54, (2012) Psoriasis causes significant distress and impairment in health-related quality of life (QOL) in afflicted patients. For this reason, QOL is an essential and important measure of treatment outcome in patients with the disease. Clobetasol propionate is a super-... |
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Clobetasol propionate spray 0.05% for the treatment of moderate to severe plaque psoriasis.
Cutis. 89(2) , 89-94, (2012) Clobetasol propionate is a super-high potent class 1 topical corticosteroid available in several formulations, including a spray formulation that is approved for use up to 4 weeks in patients aged 18 years and older with moderate to severe plaque psoriasis. T... |
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Influence of the type of vegetable oil on the drug release profile from lipid-core nanocapsules and in vivo genotoxicity study.
Pharm. Dev. Technol. 19(7) , 789-98, (2014) The use of rice bran (RB), soybean (SB) or sunflower seed (SF) oils to prepare lipid-core nanocapsules (LNCs) as controlled drug delivery systems was investigated. LNCs were prepared by interfacial deposition using the preformed polymer method. All formulatio... |
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Beefy red plaques in the perianal region.
JAMA Dermatol. 150(4) , 447-8, (2014)
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A sensitive high-throughput HPLC assay for simultaneous determination of everolimus and clobetasol propionate.
J. Chromatogr. Sci. 46(1) , 23-9, (2008) A novel sensitive high-throughput high-performance liquid chromatography assay is developed and validated for the simultaneous determination of everolimus and clobetasol propionate in pharmaceutical formulations. The chromatographic separation is achieved on ... |
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Observations on the systemic effect of topical clobetasol propionate (Dermovate).
Br. Med. J. 4(5990) , 203-4, (1975) Topical application of clobetasol propionate in a strength of 0-05% in cream or ointment (Dermovate) suppressed the hypothalamic-pituitary-adrenal axis in both normal people and patients with diseased skin. In normal people the 9 am serum cortisol level was s... |
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Topical corticosteroid reduces inflammation without compromising the efficacy of photodynamic therapy for actinic keratoses: a randomized clinical trial.
Br. J. Dermatol. 171(6) , 1487-92, (2014) Photodynamic therapy (PDT) is an effective and established treatment for actinic keratoses (AK) and nonmelanoma skin cancer. The main side-effects of PDT are post-treatment erythema and oedema, and pain during illumination. Severe erythema after PDT enhances ... |
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Topical hesperidin prevents glucocorticoid-induced abnormalities in epidermal barrier function in murine skin.
Exp. Dermatol. 23(9) , 645-51, (2014) Systemic and topical glucocorticoids (GC) can cause significant adverse effects not only on the dermis, but also on epidermal structure and function. In epidermis, a striking GC-induced alteration in permeability barrier function occurs that can be attributed... |