Fluoxetine Hydrochloride
Fluoxetine Hydrochloride structure
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Common Name | Fluoxetine Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 56296-78-7 | Molecular Weight | 345.787 | |
| Density | N/A | Boiling Point | 395.1ºC at 760mmHg | |
| Molecular Formula | C17H19ClF3NO | Melting Point | 158-159°C | |
| MSDS | Chinese USA | Flash Point | 192.8ºC | |
| Symbol |
GHS05, GHS07, GHS09 |
Signal Word | Danger | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Danzhi Xiaoyao San ameliorates depressive-like behavior by shifting toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase.
J. Ethnopharmacol. 160 , 86-93, (2014) Danzhi Xiaoyao San (DXS) is a canonical Chinese medicine formula from Principles of Internal Medicine, which was written during the Ming dynasty. This formula is approved and commercialized for use in the prevention and treatment of affective disorders. This ... |
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Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry.
J. Chromatogr. A. 1363 , 226-235, (2014) The interest for environmental fate assessment of chiral pharmaceuticals is increasing and enantioselective analytical methods are mandatory. This study presents an enantioselective analytical method for the quantification of seven pairs of enantiomers of pha... |
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The effects of chronic fluoxetine treatment following injury of medial frontal cortex in mice.
Behav. Brain Res. 290 , 102-16, (2015) Injury of the brain is a leading cause of long-term disability. Recent evidence indicates that the selective serotonin reuptake inhibitor drug fluoxetine may be beneficial when administered following brain injury. However, its potential to promote recovery an... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Removal of fluoxetine and its effects in the performance of an aerobic granular sludge sequential batch reactor.
J. Hazard. Mater. 287 , 93-101, (2015) Fluoxetine (FLX) is a chiral fluorinated pharmaceutical mainly indicated for treatment of depression and is one of the most distributed drugs. There is a clear evidence of environmental contamination with this drug. Aerobic granular sludge sequencing batch re... |
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Punarnavine, an alkaloid isolated from ethanolic extract of Boerhaavia diffusa Linn. reverses depression-like behaviour in mice subjected to chronic unpredictable mild stress.
Indian J. Exp. Biol. 52(8) , 799-807, (2014) Punarnavine (20 and 40 mg/kg) and fluoxetine (20 mg/kg) per se administered orally for 14 successive days significantly decreased immobility periods of both unstressed and stressed mice in forced swim test. These drugs also significantly decreased sucrose pre... |
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Evidence for involvement of the monoaminergic system in antidepressant-like activity of an ethanol extract of Boerhaavia diffusa and its isolated constituent, punarnavine, in mice.
Pharm. Biol. 52(6) , 767-74, (2014) Boerhaavia diffusa Linn. (Nyctaginaceae) roots possess potent antioxidant, antistress, and anticonvulsant activities. It is used as a medicinal plant in Ayurvedic and natural herbal medicines.To evaluate the effect of Boerhaavia diffusa root ethanol extract a... |
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The effects of antidepressants "fluoxetine and imipramine" on vascular abnormalities and Toll like receptor-4 expression in diabetic and non-diabetic rats exposed to chronic stress.
PLoS ONE 10(3) , e0120559, (2015) Several studies reveal that diabetes doubles the odds of comorbid depression with evidence of a pro-inflammatory state underlying its vascular complications. Indeed, little information is available about vascular effects of antidepressant drugs in diabetes.We... |
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Angelica gigas ameliorate depression-like symptoms in rats following chronic corticosterone injection.
BMC Complement Altern. Med. 15 , 210, (2015) Repeated injection of corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression. We examined the effects of Angelica gigas extract (AGN) treatment in a rat model of depressive and anxiety-like behavi... |