fenbufen
fenbufen structure
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Common Name | fenbufen | ||
|---|---|---|---|---|
| CAS Number | 36330-85-5 | Molecular Weight | 254.281 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 470.2±28.0 °C at 760 mmHg | |
| Molecular Formula | C16H14O3 | Melting Point | 184-187ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 252.3±20.5 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins
Bioorg. Med. Chem. 17 , 896-904, (2009) This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the mole... |
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Thermodynamic studies of Fenbufen, Diflunisal, and Flurbiprofen: sublimation, solution and solvation of biphenyl substituted drugs.
Int. J. Pharm. 357(1-2) , 100-7, (2008) Temperature dependency of saturated vapour pressure for Fenbufen (FBF) was obtained. Heat capacities for Fenbufen, Diflunisal (DIF), and Flurbiprofen (FBP) were measured, and standard thermodynamic functions of sublimation were calculated (FBF: DeltaGsub298=7... |
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A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Bioorg. Med. Chem. 18 , 7486-96, (2010) The displacement of probes that bind selectively to subdomains IIA or IIIA on human serum albumin (HSA) by competing compounds has been followed using fluorescence spectroscopy, and has therefore been used to assign a primary binding site for these compounds ... |
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Fabrication of aluminum terephthalate metal-organic framework incorporated polymer monolith for the microextraction of non-steroidal anti-inflammatory drugs in water and urine samples.
J. Chromatogr. A. 1393 , 1-7, (2015) Polymer monolith microextraction (PMME) based on capillary monolithic column is an effective and useful technique to preconcentrate trace analytes from environmental and biological samples. Here, we report the fabrication of a novel aluminum terephthalate met... |
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Pharmacologic properties of fenbufen.
Am. J. Med. 75(4B) , 62-9, (1983) Fenbufen (Cinopal) is an orally active nonsteroidal anti-inflammatory drug with analgesic and antipyretic activity. Like clinically used nonsteroidal anti-inflammatory drugs, it shows activity in a wide spectrum of laboratory tests in mice, rats, guinea pigs,... |
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Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents.
Eur. J. Med. Chem. 44 , 3798-804, (2009) The synthesis of a series of 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones derived from 4-oxo-4-(biphenyl-4-yl)butanoic acid (fenbufen) is described. The structures of these compounds were supported by IR, (1)H NMR, mass spectro... |
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Single dose oral fenbufen for acute postoperative pain in adults.
Cochrane Database Syst. Rev. (4) , CD007547, (2009) Fenbufen is a non-selective non-steroidal anti-inflammatory drug (NSAID), used to treat acute and chronic painful conditions. There is no known systematic review of its use in acute postoperative pain.To assess efficacy, duration of action, and associated adv... |
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Inclusion and release of fenbufen in mesoporous silica.
J. Pharm. Sci. 99(8) , 3372-80, (2010) This work reports the immobilization of Fenbufen, a nonsteroidal anti-inflammatory drug, into two different hexagonal mesoporous silicas (MCM-41) which exhibit some differences in terms of morphology and pore size, and their behavior as systems for sustained ... |
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Improved dissolution behavior of fenbufen by spherical crystallization.
Drug Dev. Ind. Pharm. 25(10) , 1073-81, (1999) Fenbufen is an analgesic, antipyretic and anti-inflammatory drug that is characterized by poor water solubility, a defect increased by very low wettability. Poor water solubility, particularly at low pH, could decrease absorption in the upper part of the gast... |
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Assessment of the effects of combination therapy with ciprofloxacin and fenbufen on the central nervous systems of healthy volunteers by quantitative electroencephalography.
Antimicrob. Agents Chemother. 42(5) , 1256-8, (1998) The potential effects of concurrent administration of fenbufen and ciprofloxacin on central nervous system activity in healthy young subjects were investigated by electroencephalography (EEG). Visual analog scales (VAS) were used to assess subjective measures... |