Propafenone hydrochloride
Propafenone hydrochloride structure
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Common Name | Propafenone hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 34183-22-7 | Molecular Weight | 377.905 | |
| Density | N/A | Boiling Point | 519.6ºC at 760 mmHg | |
| Molecular Formula | C21H28ClNO3 | Melting Point | 165-1670C | |
| MSDS | Chinese USA | Flash Point | 268ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Comparison of the therapeutic effect between sodium bicarbonate and insulin on acute propafenone toxicity
Am. J. Emerg. Med. 32(10) , 1200-7, (2014) Purpose Unlike other sodium-channel–blocking antiarrhythmic agents, propafenone has β-blocking effects and calcium-channel–blocking effects. Yi et al recently studied insulin's treatment effect on acute propafenone toxicity in rats. However, because the degre... |
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Nicotine Increases Codeine Analgesia Through the Induction of Brain CYP2D and Central Activation of Codeine to Morphine.
Neuropsychopharmacology 40 , 1804-12, (2015) CYP2D metabolically activates codeine to morphine, which is required for codeine analgesia. Permeability across the blood-brain barrier, and active efflux, suggests that initial morphine in the brain after codeine is due to brain CYP2D metabolism. Human CYP2D... |
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Conversion of recent onset atrial fibrillation: which drug is faster?
Am. J. Emerg. Med. 31(9) , 1410-1, (2013)
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Flecainide or propafenone vs. vernakalant for conversion of recent-onset atrial fibrillation.
Can. J. Cardiol. 29(10) , 1330.e13, (2013)
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Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs.
Exp. Neurol. 255 , 96-102, (2014) Although the sodium channel blocker mexiletine is considered the first-line drug in myotonia, some patients experiment adverse effects, while others do not gain any benefit. Other antimyotonic drugs are thus needed to offer mexiletine alternatives. In the pre... |
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Radiofrequency ablation as initial therapy in paroxysmal atrial fibrillation.
N. Engl. J. Med. 367(17) , 1587-95, (2012) There are limited data comparing radiofrequency catheter ablation with antiarrhythmic drug therapy as first-line treatment in patients with paroxysmal atrial fibrillation.We randomly assigned 294 patients with paroxysmal atrial fibrillation and no history of ... |
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Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes.
PLoS ONE 10 , e0131179, (2015) Flecainide blocks ryanodine receptor type 2 (RyR2) channels in the open state, suppresses arrhythmogenic Ca2+ waves and prevents catecholaminergic polymorphic ventricular tachycardia (CPVT) in mice and humans. We hypothesized that differences in RyR2 activity... |
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Antiarrhythmic drug use in patients <65 years with atrial fibrillation and without structural heart disease.
Am. J. Cardiol. 115(3) , 316-22, (2015) Little is known in clinical practice about antiarrhythmic drug (AAD) use in patients with atrial fibrillation (AF) (particularly younger ones) who do not have structural heart disease. Using the MarketScan database, we identified patients <65 years without kn... |
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[Pharmacological correction of experimental mitochondrial dysfunction of brain stem neurons by rhytmocor and mildronate].
Fiziol. Zh. 59(3) , 58-64, (2013) The results of pharmacological correction of experimental mitochondrial dysfunction in brain stem neurons after single injection of specific respiratory complex I inhibitor rotenone by complex agents mildronate and rhytmocor have been presented. It was shown ... |
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Propafenone associated severe central nervous system and cardiovascular toxicity due to mirtazapine: a case of severe drug interaction.
S. D. Med. 67(4) , 137-9, (2014) We describe a rare case of severe drug-drug interaction between propafenone and mirtazapine leading to propafenone toxicity. A 69-year-old Caucasian male taking propafenone for atrial fibrillation was prescribed mirtazapine for insomnia. Subsequent to the fir... |