Dynasore hydrate
Dynasore hydrate structure
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Common Name | Dynasore hydrate | ||
|---|---|---|---|---|
| CAS Number | 1202867-00-2 | Molecular Weight | 340.33000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16N2O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS09 |
Signal Word | Warning | |
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Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes.
Int. Immunol. 26(10) , 563-73, (2014) Toll-like receptors (TLRs) recognize a variety of microbial products and induce defense responses. Pathogen sensing by TLRs occurs either on the cell surface or in endolysosomes. TLR-dependent responses are greatly influenced by the site of pathogen sensing. ... |
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Myosin Vb mediated plasma membrane homeostasis regulates peridermal cell size and maintains tissue homeostasis in the zebrafish epidermis.
PLoS Genet. 10(9) , e1004614, (2014) The epidermis is a stratified epithelium, which forms a barrier to maintain the internal milieu in metazoans. Being the outermost tissue, growth of the epidermis has to be strictly coordinated with the growth of the embryo. The key parameters that determine t... |
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Renal type a intercalated cells contain albumin in organelles with aldosterone-regulated abundance.
PLoS ONE 10(4) , e0124902, (2015) Albumin has been identified in preparations of renal distal tubules and collecting ducts by mass spectrometry. This study aimed to establish whether albumin was a contaminant in those studies or actually present in the tubular cells, and if so, identify the a... |
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Niemann-Pick C1 affects the gene delivery efficacy of degradable polymeric nanoparticles.
ACS Nano 8(8) , 7905-13, (2014) Despite intensive research effort, the rational design of improved nanoparticulate drug carriers remains challenging, in part due to a limited understanding of the determinants of nanoparticle entry and transport in target cells. Recent studies have shown tha... |
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Dynasore disrupts trafficking of herpes simplex virus proteins.
J. Virol. 89 , 6673-84, (2015) Dynasore, a small-molecule inhibitor of the GTPase activity of dynamin, inhibits the entry of several viruses, including herpes simplex virus (HSV), but its impact on other steps in the viral life cycle has not been delineated. The current study was designed ... |
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P2X7 Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance.
J. Immunol. 195 , 1191-201, (2015) Bioactive peptide LL-37/hCAP18, the only human member of the cathelicidin family, plays important roles in killing various pathogens, as well as in immune modulation. We demonstrate that LL-37 is internalized by human macrophages in a time-, dose-, temperatur... |
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Internalization of coxsackievirus A9 is mediated by {beta}2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin.
J. Virol. 84 (7) , 3666-81, (2010) Coxsackievirus A9 (CAV9) is a member of the human enterovirus B species within the Enterovirus genus of the family Picornaviridae. It has been shown to utilize alphaV integrins, particularly alphaVbeta6, as its receptors. The endocytic pathway by which CAV9 e... |
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Transcytosis of HIV-1 through vaginal epithelial cells is dependent on trafficking to the endocytic recycling pathway.
PLoS ONE 9(5) , e96760, (2014) While it is accepted that viruses can enter epithelial cells by endocytosis, the lack of an established biological mechanism for the trafficking of infectious virions through vaginal epithelial cells and their release from the plasma membrane has contributed ... |
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Entry properties and entry inhibitors of a human H7N9 influenza virus.
PLoS ONE 9(9) , e107235, (2014) The recently identified human infections with a novel avian influenza H7N9 virus in China raise important questions regarding possible risk to humans. However, the entry properties and tropism of this H7N9 virus were poorly understood. Moreover, neuraminidase... |
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Hip fractures and bone mineral density in the elderly--importance of serum 25-hydroxyvitamin D.
PLoS ONE 9(3) , e91122, (2014) The significance of serum 25-hydroxyvitamin D [25(OH)D] concentrations for hip fracture risk of the elderly is still uncertain. Difficulties reaching both frail and healthy elderly people in randomized controlled trials or large cohort studies may in part exp... |