GppCp(GMPPCP)
GppCp(GMPPCP) structure
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Common Name | GppCp(GMPPCP) | ||
|---|---|---|---|---|
| CAS Number | 10470-57-2 | Molecular Weight | 587.15 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H15N5Na3O13P3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Polarized endosome dynamics by spindle asymmetry during asymmetric cell division.
Nature 528 , 280-5, (2015) During asymmetric division, fate determinants at the cell cortex segregate unequally into the two daughter cells. It has recently been shown that Sara (Smad anchor for receptor activation) signalling endosomes in the cytoplasm also segregate asymmetrically du... |
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Dynamic and thermodynamic response of the Ras protein Cdc42Hs upon association with the effector domain of PAK3.
J. Mol. Biol. 426(21) , 3520-38, (2014) Human cell division cycle protein 42 (Cdc42Hs) is a small, Rho-type guanosine triphosphatase involved in multiple cellular processes through its interactions with downstream effectors. The binding domain of one such effector, the actin cytoskeleton-regulating... |
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Regulation of human tissue transglutaminase function by magnesium-nucleotide complexes. Identification of distinct binding sites for Mg-GTP and Mg-ATP.
J. Biol. Chem. 273 , 1776-1781, (1998) Tissue transglutaminase (tTG) catalyzes a Ca(2+)-dependent transglutaminase (TGase) activity that stabilizes tissues and a GTP hydrolysis activity that regulates cell receptor signaling. The purpose of this study was to examine the true substrates for nucleot... |
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Functional characterization of solute carrier (SLC) 26/sulfate permease (SulP) proteins in membrane mimetic systems.
Biochim. Biophys. Acta 1858 , 698-705, (2016) Solute carrier (SLC) 26 or sulfate permease (SulP) anion transporters, belong to a phylogenetically ancient family of secondary active transporters. Members of the family are involved in several human genetic diseases and cell physiological processes. Despite... |
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The crystal structure of the signal recognition particle in complex with its receptor.
Science 331 , 881-886, (2011) Cotranslational targeting of membrane and secretory proteins is mediated by the universally conserved signal recognition particle (SRP). Together with its receptor (SR), SRP mediates the guanine triphosphate (GTP)-dependent delivery of translating ribosomes b... |
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LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.
PLoS ONE 6 , e23207, (2011) Leucine rich repeat kinase 2 (LRRK2) is a Parkinson's disease (PD) gene that encodes a large multidomain protein including both a GTPase and a kinase domain. GTPases often regulate kinases within signal transduction cascades, where GTPases act as molecular sw... |
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Identification of the binding surface on Cdc42Hs for p21-activated kinase. Guo W, Sutcliffe MJ, et al.
Biochemistry 37 , 14030-14037, (1988)
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A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke.
Cell 147 , 209-222, (2011) The GTPase dynamin catalyzes membrane fission by forming a collar around the necks of clathrin-coated pits, but the specific structural interactions and conformational changes that drive this process remain a mystery. We present the GMPPCP-bound structures of... |
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The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+.
J. Mol. Biol. 266 , 847-857, (1997) GTP and ATP hydrolysing proteins have an absolute requirement for a divalent cation, which is usually Mg2+, as a cofactor in the enzymatic reaction. Other phosphoryl transfer enzymes employ more than one divalent ion for the enzymatic reaction. It is shown he... |
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Structure of the GMPPNP-stabilized NG domain complex of the SRP GTPases Ffh and FtsY.
J. Struct. Biol. 158 , 122-128, (2007) Ffh and FtsY are GTPase components of the signal recognition particle co-translational targeting complex that assemble during the SRP cycle to form a GTP-dependent and pseudo twofold symmetric heterodimer. Previously the SRP GTPase heterodimer has been stabil... |